DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and alpha-Est2

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	588	Identity:	164/588 - (27%)
Similarity:	257/588 - (43%)	Gaps:	103/588 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VGLGLIIVLSCLWLGSNAS----DTDDPLLVQLPQGKLRG------RDNGSYYSYESIPYAEPPT 58
            ||...:|.:....:|....    .|...:::....|::||      .|...|:::|.||||:||.
  Fly     5 VGWPKLIKMGAQLVGHKVQQYRLSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPV 69

  Fly    59 GDLRFEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLV----GEEDCLTVSVYKPKNSKRN 119
            |||||.||:| .:.|..:.:.|......:|       .|.|:    |.||||.::||........
  Fly    70 GDLRFRAPQP-PEPWQGVLNCTTNRSKPMQ-------RNMLLGIVEGSEDCLHLNVYVKALKSEK 126

  Fly   120 SFPVVAHIHGGAFMFGAAWQNGHE-NVMREGKFILVKISYRLGPLGFVSTGD--RDLPGNYGLKD 181
            ..||:..|:||.|..|.|.::.:. :...:...:.|.|:|||..|||:|..|  .|:|||.||||
  Fly   127 PLPVIVWIYGGGFQKGEASRDIYSPDYFMKKPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKD 191

  Fly   182 QRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQK 246
            |.:||:||.||||.|.|:|.|:.|:|.|||.||||:.|..|....|...|...||.||..|| :.
  Fly   192 QVMALRWISQNIAHFNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWV-ES 255

  Fly   247 GARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTA----------VRKFLIFSYVPFAPFS 301
            .....||.|.:|:|.:..|....:...| ||..:..:.|          ||.||:|:      |.
  Fly   256 PDNNWAFRLAQNLGYKGDEKDADVLSFL-SKVCARQIAAIDQDVINLDEVRSFLLFA------FG 313

  Fly   302 PVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWL 366
            ||:||.:....::.:..:|::.......:|..|...:.:|.::..|:.|:
  Fly   314 PVIEPYETDHCVVPKRHKDLLSEAWGNDIPVIVGGNSFEGLFSYQLVRKD--------------- 363

  Fly   367 ELAPYLL--FY-------RDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNST 422
               |:.|  |:       |:|.:.:..|...|::||.|..|:..:.....|...:|:.....:.|
  Fly   364 ---PWALKNFHNILPREVRETSSLEGQDLLVRRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDT 425

  Fly   423 QESLDLHRKYG-KSPAYAY--VYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFENFV------ 478
            ...:...:.|. |:|.|.|  .:|:|......:::..  |...|..|.|:...:|.|.:
  Fly   426 HRFILARQSYAPKTPTYLYRFDFDSPHFNQFRRLVCG--DRIRGVAHADELSYLFYNIIASKLDK 488

  Fly   479 RDVEMRPDEQIISRNFINMLADFASSDN------GSLKYGECDFKDNVGSEKFQLLAIYIDGCQN 537
            ..:|.:..|::     :.|...||||.|      ||.|:.....|:|.           ::.|.|
  Fly   489 SSMEYKTIERM-----VGMWTSFASSGNPNCPELGSAKWEAVQLKENA-----------VEKCFN 537

  Fly   538 RQH 540
            ..|
  Fly   538 ISH 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	157/554 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	58/135 (43%)
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	154/531 (29%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	44/103 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440355
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.790