DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and alpha-Est3

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001163540.1	Gene:	alpha-Est3 / 40907	FlyBaseID:	FBgn0015571	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	158/538 - (29%)
Similarity:	236/538 - (43%)	Gaps:	101/538 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DPLLVQLPQGKLRGRD-----NGSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVA 85
            :.|.|....|.:.|:.     ...|.|:|.||||:||.|.|||.||.|. :.||...|.||....
  Fly     2 ESLQVNTTSGPVLGKQCTGVYGDEYVSFERIPYAQPPVGHLRFMAPLPV-EPWSQPLDCTKPGQK 65

  Fly    86 CLQWDQFTPGANKLVGEEDCLTVSVYKPKNSKRNSFPVVAHIHGGAFMFGAAWQNGHEN---VMR 147
            .||::.:   :.:|.|.||||.::||..:.......|::....||.|..|...:..|..   :||
  Fly    66 PLQFNHY---SKQLEGVEDCLYLNVYAKELDSPRPLPLIVFFFGGGFEKGDPTKELHSPDYFMMR 127

  Fly   148 EGKFILVKISYRLGPLGFVSTGDR--DLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSA 210
            :  .::|.:|||:|||||:|..|.  .:|||.|||||.||::|||:|...|.|:|:||...|.||
  Fly   128 D--VVVVTVSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESA 190

  Fly   211 GGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVGCESAEDSTS--LKKC 273
            |.||||..||......|...|...|||.|..|.:.. .:.....|..|:|.||||..|.  :...
  Fly   191 GAASVHYLMLNPKAEGLFHKAILQSGNVLCSWALCT-IKNLPHRLAVNLGMESAEHVTDAMVLDF 254

  Fly   274 LKSKPASELVTAVRKFL----------IFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFG 328
            |:..|..:|   ||.:|          :|.      |.|::||.......:...|::::......
  Fly   255 LQKLPGEKL---VRPYLLSAEEHLDDCVFQ------FGPMVEPYKTEHCALPNHPQELLDKAWGN 310

  Fly   329 QVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFYRDTKTKKDMD-----DYS 388
            ::|..:|..:.:|     ||:..|             :::|||||    |..||:.:     |..
  Fly   311 RIPVLMSGTSFEG-----LLMYAR-------------VQMAPYLL----TSLKKEPEHMLPLDVK 353

  Fly   389 RKIKQ---EYIGNQRF----------------DIESYSEL--QRLFTDILFKNSTQESLDLHRKY 432
            |.:.|   .::| ||.                .:::|.|.  .::|...:.|.       |..:.
  Fly   354 RNLPQALARHLG-QRLQETHFGGNDPSAMSPESLKAYCEYASYKVFWHPILKT-------LRSRV 410

  Fly   433 GKSPAYAYVY----DNPAEKGIAQVLANRTDYDFGTVHGDDY-FLIFENFVRDVEMRPDEQIISR 492
            ..|.|..|:|    |:|...  .|.|....|...|..|.||: :|.:.:|...::....|.:...
  Fly   411 KSSSASTYLYRFDFDSPTFN--HQRLKYCGDKLRGVAHVDDHSYLWYGDFSWKLDKHTPEFLTIE 473

  Fly   493 NFINMLADFASSDNGSLK 510
            ..|:||..||.:.|.:.|
  Fly   474 RMIDMLTSFARTSNPNCK 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	157/535 (29%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	56/137 (41%)
alpha-Est3	NP_001163540.1	Abhydrolase	3..529	CDD:304388	158/537 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440356
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.790