DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and alpha-Est5

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	145/540 - (26%)
Similarity:	239/540 - (44%)	Gaps:	74/540 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LPQGKLRGRDNGS-----YYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQWDQ 91
            ||.|:::|....|     |:|:|.||:|:||.|:|||.||.| ...||.:.|.|.......|...
  Fly    15 LPVGQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVP-ADPWSGVLDCTHYAEKPTQRGL 78

  Fly    92 FTPGANKLVGEEDCLTVSVYKPKNSKRNSFPVVAHIHGGAFMFGAAWQN--GHENVMREGKFILV 154
            .|   .::.|.||||.::||..:.......||:.:|:||||..|.|.:.  |.:..|.: ..:||
  Fly    79 LT---REIEGGEDCLYLNVYSKQLKSEKPLPVMVYIYGGAFTVGEATRELYGPDYFMTK-DVVLV 139

  Fly   155 KISYRLGPLGFVSTGDRDL--PGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHL 217
            .::||:..|||:|..|..|  |||.|||||.|||||:||.|::|.|:..|:.:.|.||||.|.|.
  Fly   140 TLNYRVDCLGFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGESAGGCSTHF 204

  Fly   218 QMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASEL 282
            .|..|....|...|...||...:.|. ...|...||.|.:..|.....|...:.:.|:..||.:|
  Fly   205 MMCTEQTRGLFHKAIPMSGTVHNYWA-NNPAEDFAFRLAQQNGFTGENDDAKVLEYLQGVPARDL 268

  Fly   283 VT-------AVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTED 340
            |.       ..|..|:|:      |.|.:|.....|.::.:.|.::.:..      |:.::....
  Fly   269 VNHNLLTPEHRRNGLLFA------FGPTVEAYVGEDCVVPKPPVEMARDA------WSNNFPVML 321

  Fly   341 GG--YNAALLLKERKSGI-VIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFD 402
            ||  :....:.....:.: .:|.|::....|.|  :..|...::|:..:||:::.:.|.|.....
  Fly   322 GGTSFEGLFMYPAVSANLKALDSLSQDPTRLVP--VDVRTVSSEKENLEYSQRLMKAYFGYSPPS 384

  Fly   403 IESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDF----- 462
            .|....:...::..:|.:....:.:....|.|:|.|.|.:|           .:..:::|
  Fly   385 SELLLNMLDFYSYKIFWHGFNRTFNARLTYAKAPTYYYRFD-----------FDSPNFNFYRAKF 438

  Fly   463 -------GTVHGDDYFLIFENF------VRDVEMRPDEQIISRNFINMLADFASSDNGSL-KYGE 513
                   |..|.||...:|.|.      ....|.|..|::     |.:...||::.|.:. :.|.
  Fly   439 CGDKIKTGVAHADDLSYLFRNAGSWKLDKTSAEYRTIERM-----IGIWTAFAATSNPNCPEIGH 498

  Fly   514 CDFKDNVGSEKFQLLAIYID 533
            .::|.:..::..:::.|..|
  Fly   499 LEWKPSTKNDPKRVINISSD 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	145/540 (27%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	55/136 (40%)
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	143/530 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440359
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.790