DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and alpha-Est6

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	149/525 - (28%)
Similarity:	241/525 - (45%)	Gaps:	77/525 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SCLWLGSNASDTDDPLLVQLPQGKLRGRD-NGSY----YSYESIPYAEPPTGDLRFEAPEPYKQK 72
            ||    .:|.|.|.. :|:|..|.::||. :|.|    ||:|.||:|:||.|..||.|.: ....
  Fly    31 SC----QSAGDADSK-VVKLSVGSVKGRRLSGIYGDEFYSFEGIPFAKPPLGKARFVASQ-LADP 89

  Fly    73 WSDIFDATKTPVACLQWDQFTPGANKLVGEEDCLTVSVY-KPKNSKRNSFPVVAHIHGGAFMFGA 136
            |:...||.:.....||.|:   .:.|:||.||||.::|| |..|......||:.:|:||||..|.
  Fly    90 WNSELDARQERPIPLQMDR---RSGKVVGSEDCLYLNVYTKHFNESEPPLPVMVYIYGGAFRTGG 151

  Fly   137 AWQN--GHENVM-REGKFILVKISYRLGPLGFVS--TGDRDLPGNYGLKDQRLALKWIKQNIASF 196
            |.::  |.:.:| |:..::|  .:|||..|||:|  :|..|:|||.||.||.|||:|:.|:|.:|
  Fly   152 AVKSKYGPDYLMSRDVVYVL--FNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNF 214

  Fly   197 GGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVGC 261
            .|:|||:.|.|.|||.||||..|.......|...|...||:.|.|||....:.|....|..:.|.
  Fly   215 NGDPQNITLFGESAGAASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGY 279

  Fly   262 ESAEDSTSLKKCLKSKPASELVTAVRKFL-----IFSYVPFAPFSPVLEPSDAPDAIITQDPRDV 321
            |...:...:.:.|::..|.:|:.  ..|:     .|.::  .||:||:      ..::....:.:
  Fly   280 EGPAEEVPILEFLRNVNAEKLIG--HDFISPRDRCFGFL--NPFAPVV------GGLVAAPFQQL 334

  Fly   322 IKSGKFGQVPWAVS-----------YVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLF- 374
            :|.....:||..:.           :...|.||...||  :.:..:|:           |:.|:
  Fly   335 MKEAWSCEVPLLLGGTSFEGLVYYPFCQLDNGYMLELL--KHEPAMVL-----------PHELYQ 386

  Fly   375 ---YRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHRKYGKSP 436
               ..:..|..|:     .:|..| |.:.....:.:::..||:..||.:.....:.....:.::|
  Fly   387 SMSVEERNTAADV-----LVKYHY-GPRGITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQAP 445

  Fly   437 AYAYVYDNPAEKGIAQVLANR---TDYDFGTVHGDDYFLIFENFVRDVE-MRPDEQIISRNFINM 497
            .|.|.:|..:.|  ..::.|:   .|...|..|.||...||....:..: :...|.:..:..:.:
  Fly   446 TYLYRFDFDSPK--LNLMRNQLCGDDIKRGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGI 508

  Fly   498 LADFA 502
            |..||
  Fly   509 LTTFA 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	144/509 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	60/138 (43%)
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	147/517 (28%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	71/203 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440360
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.790