DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and alpha-Est8

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	157/533 - (29%)
Similarity:	245/533 - (45%)	Gaps:	92/533 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 TDDPLLVQLPQGKLRGRD-----NGSYYSYESIPYAEPPTGDLRFEAP-EPYKQKWSDIFDATKT 82
            ::|.::.....||::|..     ..:|||:|.||:|:||.|:|||:|| ||  :.|||:...|..
  Fly    29 SNDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEP--EHWSDVKRCTHV 91

  Fly    83 PV-ACLQWDQFTPGANKLVGEEDCLTVSVYKPKNSKRNSFPVVAHIHGGAFMFGAAWQN--GHEN 144
            .. .|    |......::.|.||||.::||..:.......||:..|:||.|..|.|.::  ..:.
  Fly    92 RAKPC----QVNIVLKQVQGSEDCLYLNVYTRELHPHRPLPVLVWIYGGGFQMGEASRDLYSPDY 152

  Fly   145 VMREGKFILVKISYRLGPLGFVSTGDR--DLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVG 207
            :|.| ..:||.||||||.|||:|..|.  |:|||.|||||.:||:|:|:|...|||:|.|:.:.|
  Fly   153 IMME-HVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFG 216

  Fly   208 HSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVG-CESAEDS---T 268
            .||||||.|..||.:....|.......||:||.||..........:.|.:..| ...|.|.   .
  Fly   217 ESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDANDRDIFA 281

  Fly   269 SLKKCLKS---KPASELVTAV---RKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKF 327
            .||||..|   |.|.:::|..   ::..:||      |.|.:||...|..:|.:.|.::::....
  Fly   282 HLKKCKASSMLKVAEDIITMEERHQRLTMFS------FGPTIEPYLTPHCVIPKSPLEMMRDCWG 340

  Fly   328 GQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYL-----LFYRDTKT-KKDMDD 386
            ..:|..:      ||.:...||       :..::| :|.||...|     |..:|... ::....
  Fly   341 NSIPMVI------GGNSFEGLL-------MFPEVN-KWPELLCQLGDCENLAPQDAHVDEQQRKA 391

  Fly   387 YSRKIKQEYIGNQ---RFDIESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEK 448
            :.:|:::.|.|::   |..|..||:   ||:...|.:....:| |.|.:....|..::|
  Fly   392 FGKKVRELYFGDRTPGRKTILEYSD---LFSYKYFWHGIHRTL-LSRAHHAPLAPTFLY------ 446

  Fly   449 GIAQVLANRTDYDF----------------GTVHGDDYFLIFEN-FVRDVEMRPDEQIISRNFIN 496
                    |.|:|.                ||.|.||...:|.| ..:.::.|..|....:..::
  Fly   447 --------RFDFDSKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVS 503

  Fly   497 MLADFASSDNGSL 509
            |:..||.|.:.::
  Fly   504 MVVHFAISGDPNI 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	156/528 (30%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	60/136 (44%)
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	157/533 (29%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	47/105 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440352
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.800