DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Jhe

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	166/563 - (29%)
Similarity:	259/563 - (46%)	Gaps:	48/563 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IIVLSCLWLGSN----ASDTDDPLLVQLPQ-GKLRGRDNGSYYS-----YESIPYAEPPTGDLRF 63
            :::|..|..|..    |..|.|.|.|..|. |.|:|.:...|.|     :..||||.||.|||||
  Fly     9 LLLLGQLLAGPGPFCAALATVDQLTVCPPSVGCLKGTNLQGYQSERFEAFMGIPYALPPIGDLRF 73

  Fly    64 EAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVGEEDCLTVSVYKPKNSKRNSFPVVAHIH 128
            ..|: ...|...::||:...:.|:|.:...| ...:.|:||||.::||:|: .::::.||:.:||
  Fly    74 SNPK-VMPKLLGMYDASAPKMDCIQKNYLLP-TPVVYGDEDCLYLNVYRPE-IRKSALPVMVYIH 135

  Fly   129 GGAFMFGAAWQ--NGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQ 191
            ||.|..|:|..  .|.|..|..|:.|||.::|||||.||:||.|..:.||:|||||.|||:|:::
  Fly   136 GGGFFGGSAGPGVTGPEYFMDSGEVILVTMAYRLGPFGFLSTQDAVMSGNFGLKDQNLALRWVQR 200

  Fly   192 NIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELG 256
            ||..|||:||.|.:.|.||||.:.|:.:|......|.....|.||.|..|:.|.:....:|..|.
  Fly   201 NIRFFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLLA 265

  Fly   257 RNVGCESAEDSTSLK--KCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPR 319
            .......|.:.:::|  |.|:...|::|:.|......:.......|.||:|.....||.:...|.
  Fly   266 EFADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMTNFRPVVEEGLEVDAFLNAHPM 330

  Fly   320 DVIKSGKFGQVPWAVSYVTEDGGYNAALLLKE---RKSGIVIDDLNERWLELAPYLL-----FYR 376
            |::..|....:|..:..|..:|......:|..   |:|      .|.|:.||...||     |.:
  Fly   331 DMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNETLRQS------FNLRFDELLQELLEFPASFSQ 389

  Fly   377 DTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYV 441
            | :.:|.||   ..::..:.|....:..:......|.:|..||.....::..:..:..:|.|.|.
  Fly   390 D-RREKMMD---LLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVCHTPNPVYLYS 450

  Fly   442 --YDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFEN--FVRDVEMRPDEQIISRNFINMLADFA 502
              |..|.....|...||.|. .:|.||.||...:|.:  ...|.:....|..:..:|::....||
  Fly   451 FNYQGPLSYASAYTSANVTG-KYGVVHCDDLLYLFRSPLLFPDFQRNSTEAKVIHSFVDYFVHFA 514

  Fly   503 SSDNGSLKYGECDFKDNVGSEKFQLLAIYIDG-CQNRQHVEFP 544
                   |:|:....:::.....::|....|| |...:....|
  Fly   515 -------KFGKPRNSESLTPCSIEVLQSRPDGICDYHEFANAP 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	158/530 (30%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	61/134 (46%)
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	152/507 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440341
Domainoid	1	1.000	183	1.000	Domainoid score	I2040
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I2624
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.890