DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Jhedup

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	171/572 - (29%)
Similarity:	289/572 - (50%)	Gaps:	63/572 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNYVGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGR-----DNGSYYSYESIPYAEPPTGD 60
            |.:.|.|::     |::.....|:.|..|..:  |.:||.     .:|.:.::..||:|:||.|.
  Fly     1 MLFAGFGVL-----LFVAVAVGDSLDVCLEDM--GCMRGTLMPGYQSGEFEAFMGIPFAQPPVGP 58

  Fly    61 LRFEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVGEEDCLTVSVYKPKNSKRNSFPVVA 125
            ||.:.|.| .:.|..:.||.....:|:|...|..... |:|.||||.::||:|||...:..||:.
  Fly    59 LRLKNPVP-NEPWEGVLDAGAAKDSCIQRSYFAKEWG-LMGVEDCLYLNVYRPKNRAEDKLPVMV 121

  Fly   126 HIHGGAFMFGAA--WQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKW 188
            :||||.|..|:|  ..:|.|.:|...|.::|.::|||||.||:||||..:|||:|.|||||||:|
  Fly   122 YIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQW 186

  Fly   189 IKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNA-LDPWVIQKGARGRA 252
            |:::||:|||:|:.|.::||||||.|.||.|:..:...|.:.:.|.:|.. |....|.|....:|
  Fly   187 IQKHIATFGGDPKKVTVLGHSAGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQA 251

  Fly   253 FELGRNVGCESAE--DSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIIT 315
            ..||:.:..:.||  .|..|.:.|::....:|:.:|....::..:|.....|||| :.:|||.:.
  Fly   252 RRLGKELAIDQAESLSSQDLAEALRNVCPKKLLVSVDSLKVWDNMPHLTTLPVLE-APSPDAFLV 315

  Fly   316 QDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFYRD--- 377
            :||.|..::|:..|:||.:| ::...|..:..:::...:..:..:.||.:||....||...:
  Fly   316 EDPLDAHRAGRINQMPWILS-LSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALLLNLPEGTP 379

  Fly   378 -TKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHRKYG---KSPAY 438
             ....:.:|.|.  .|.:.:.|     ::..:|..:..|..|.....|::..:..|.   ::|.:
  Fly   380 VQMVSEILDAYD--FKGDSLNN-----DTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLF 437

  Fly   439 AYVYDNPAEKGIAQVLANRT-DYDFGTVHGDDYF------LIFENFVRDVEMRPDEQIISRNFIN 496
            .|:::......|.:..|..| ||..|.||.||..      :.|::|.:|.|   |.::|.| ..:
  Fly   438 IYIFEFAGLNSITKFFAGTTDDYGLGAVHMDDGLHTIRIPVSFDDFPKDSE---DAKVIQR-MSS 498

  Fly   497 MLADFASS----DNGSLKYGECDFKD-------NVGSEKFQLLAIYIDGCQN 537
            ::.|||.:    :....|..  |||:       :.|..|.:    |::..:|
  Fly   499 LMTDFAKTGVFHEESICKVS--DFKEQGMCNYLHFGGNKEK----YLEDIRN 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	164/542 (30%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	64/135 (47%)
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	155/491 (32%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	54/103 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440340
Domainoid	1	1.000	183	1.000	Domainoid score	I2040
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I2624
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.890