DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and CG12869

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	128/562 - (22%)
Similarity:	227/562 - (40%)	Gaps:	124/562 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VQLPQGKLRG------RDNGSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQ 88
            ::|.||.|.|      ...|:.|::..||||:.|..:||| ||......::....||.....|.|
  Fly    31 IKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRF-APAKPSSSFNRTLQATTMQPLCPQ 94

  Fly    89 -----WDQFTPGA--NKLVGEEDCLTVSVYKPKNSKR-NSFPVVAHIHGGAFMFGAAWQNGHEN- 144
                 :|:.:.|:  ..:..:||||.::::.|::..| ...|:|..:.|..|.:.  |.....|
  Fly    95 LANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVVIVTGEEFAYD--WPRNRING 157

  Fly   145 --VMREGKFILVKISYRLGPLGFVSTGD--RDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLL 205
              :..|| .::|.:.||....|::|.|:  |::||||||.|.::||:||::|..:|||.|.::.|
  Fly   158 LDLAGEG-IVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITL 221

  Fly   206 VGHSAGGASVHLQMLREDFGQLARAAFSFSGNAL-------DPWVIQKGARGRAFELGRNVGCES 263
            :||.:|||.:.|....||..|:.:......|..:       ..|:::.|.     .|.:.:||:.
  Fly   222 LGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVETGQ-----VLVQKLGCQF 281

  Fly   264 AE-DSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKF 327
            .| ....|..||:.|...:|:.|...  ::::...:....|:.|...|   :.|..|:....
  Fly   282 EEAQRRQLMGCLRRKSREDLLRAYES--VYNHGNGSSQLGVILPEGLP---LEQRLRNKTLP--- 338

  Fly   328 GQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIK 392
               |..:...:.:|.:                 |.:.||::|           ::......:.|.
  Fly   339 ---PVLLGITSNEGAF-----------------LQDYWLDVA-----------REGQVALHKYIN 372

  Fly   393 QEYIGNQRFDIESYSE---------------------------LQRLFTDILFKNSTQESLDLHR 430
            ...:.|....:||..|                           :|||.::.|::......|:|
  Fly   373 HTLLPNVMRALESVGEESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLSESLYELPYSRILEL-- 435

  Fly   431 KYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFL-----IFENFVRDVEMRPDEQII 490
             ...:.:||||:|:    ..:..:..|.:...|..|..|..|     :|:...|. ....:|:.:
  Fly   436 -LNGTTSYAYVFDH----SHSMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIARR-RFSGEEEQL 494

  Fly   491 SRNFINMLADFASSDN--------GSLKYG-ECDFKDNVGSE 523
            .|......|:|..:.|        |.|.|. |..|..::|.:
  Fly   495 CRKIRGAFANFIKNGNPTPGRIYDGWLPYNKENPFVYSLGEQ 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	128/562 (23%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	44/145 (30%)
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	128/562 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910