DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Gli

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	154/551 - (27%)
Similarity:	240/551 - (43%)	Gaps:	114/551 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DTDDPLLVQLPQGKLRGRDNGSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACL 87
            |..||.....|......|..|....:..||||.|||.:.||:.|..:: .| .:..|.....||.
  Fly   153 DNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHR-GW-QLLQAVDFGPACP 215

  Fly    88 QWDQFTPGANK--LVGEEDCLTVSVYKPKNSK--RNSFPVVAHIHGGAFMFGAA--WQNGHENVM 146
            |..::| ||.|  :..:||||.::||.||...  ...:||:.:||||.|:.||:  :| ||  ::
  Fly   216 QPVRYT-GATKGIMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIRGASNLFQ-GH--IL 276

  Fly   147 REGKF---ILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGH 208
              ..|   ::|.::||||.|||:||||.:.|||||:.||.:||:|:..||..|.|:..::.|.|.
  Fly   277 --ASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGP 339

  Fly   209 SAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVI---QKGARGRAFELGRNVGCESAEDSTSL 270
            .|||||..|.|:......:.|...:.||:||..|.:   :..|:..:..||:.:|| |.|.|..|
  Fly   340 GAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGC-SIESSWKL 403

  Fly   271 KKCLKSKPASELVTAVRKFLIFSYVPFA------PFSPVLE-----PSD-------APD-AIITQ 316
            ..||::.         |.|.......|:      |:.|||:     |.|       ..| ..:||
  Fly   404 VNCLRTG---------RSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQ 459

  Fly   317 DPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFYRDTKTK 381
            .|..:|::|||.:   .:.|:|......||..:.:.:|             |:||.
  Fly   460 TPETLIRAGKFNR---NIQYMTGVTTQEAAFFVAQNES-------------LSPYY--------- 499

  Fly   382 KDMDD--YSRKIKQEYIGNQRFDIES---YSELQRLFT--------------------DILFKNS 421
             ::|.  :.:||: |::....:.:..   |..::.::|                    |:.::..
  Fly   500 -ELDGRFFDQKIR-EHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAP 562

  Fly   422 TQESLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFENFVRDVEMRPD 486
            ..:.:.|..:. |.|.|.||.:...|   |..|.....|....   :.|||....|: |.|..|.
  Fly   563 VDQMVKLMLEQ-KVPVYMYVLNTTVE---ALNLPQWRKYPHDI---ERYFLTGAPFM-DTEFFPK 619

  Fly   487 EQIISRNF-----INMLADFASSDNGSLKYG 512
            ::.:.||.     .||...|..:.....:||
  Fly   620 KEHLQRNMWTDNDRNMSHFFMQTYTNFARYG 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	151/545 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	57/139 (41%)
Gli	NP_476602.1	COesterase	134..695	CDD:278561	154/551 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440344
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.740