DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and CG4382

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_609301.2	Gene:	CG4382 / 34279	FlyBaseID:	FBgn0032132	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	591	Identity:	157/591 - (26%)
Similarity:	256/591 - (43%)	Gaps:	102/591 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GLIIVLSCLWLGSNAS--------DTDDP---------LLVQLPQGKLRG-----RDNGSYYSYE 49
            |.:::|..|..|.|:.        |.:||         |::....||:||     :...::|::.
  Fly     6 GFVLLLCGLASGQNSDEDLSKAIPDEEDPIGSNKELSDLVITTALGKIRGTILPSQSGRNFYAFR 70

  Fly    50 SIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVGE--EDCLTVSVYK 112
            .||||:||...|||:.|||.:| |.|..|||.....|       |....:.|:  ||||.|::|.
  Fly    71 GIPYAKPPVDRLRFQPPEPVEQ-WFDTLDATFDGPKC-------PQLGLVSGDVSEDCLRVNIYT 127

  Fly   113 ---PKNSKRN-SFPVVAHIHGGAFMFGAAWQN----GHENVMREGKFILVKISYRLGPLGFVSTG 169
               |..|:.| ..||:..||.|.| :..:.|:    |.:..|.. :.:||..:||||.|||::||
  Fly   128 KELPSESQPNVRRPVIVFIHPGGF-YSLSGQSKNFAGPQYFMNR-RLVLVTFNYRLGSLGFLATG 190

  Fly   170 DRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSF 234
            .|:.|||.|||||...|:|:|.:|:.|||:|.::.|:|:.||..:|.|.|:......|...|...
  Fly   191 TREAPGNMGLKDQVQLLRWVKLHISRFGGDPSSITLLGYGAGAMAVTLHMVSPMSRGLFHKAIVM 255

  Fly   235 SGNALDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFS-YVPFA 298
            ||.....|.:.......|.:....:.|.: |:.|.:..|||.|...|....:.|...|. ..|..
  Fly   256 SGAVTGQWSLPDHQMDVATKQATLLHCHT-ENVTEMMDCLKGKHYLEFANTLPKMFEFDRNNPLI 319

  Fly   299 PFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNE 363
            .:.||:||....:..:.::|....::..|.:|| .::.:|:|.....||.:.:  |..::..|||
  Fly   320 LWKPVIEPDFGQERFLVEEPIRSYQNDDFMKVP-IITGMTKDEFVGPALSILQ--SPTLLSALNE 381

  Fly   364 RWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDI-ESYSELQRLFTDILFKNSTQESLD 427
            .:..|||....|..:..:  ..:.|::::..|..::..|. .|...|..|::|.|........:.
  Fly   382 NFESLAPVFFMYNTSDAR--ACNISQELRNHYFPDKLIDANRSLEALSNLYSDALTGFGIHRFVH 444

  Fly   428 LHRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFENFVRDVEMRPDEQIISR 492
            |..:..|...|.:.|     :|....:....|..:|.||.||...:|.           |..|||
  Fly   445 LAARSTKVYYYRFSY-----QGARSHIYYPEDAPYGVVHHDDLMYLFV-----------EPSISR 493

  Fly   493 NF-------------INMLADFASSDNGS---------LKYGECDFK--------------DNVG 521
            .|             :.|.:.||...:.:         :::....||              :|:.
  Fly   494 MFTEDDDEFRMVDIMVRMFSAFAYKGDPNKPTDLALRDIRWRPFSFKKRYYLDIGKHITLEENLN 558

  Fly   522 SEKFQL 527
            :|.:::
  Fly   559 AENYEI 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	148/552 (27%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	52/140 (37%)
CG4382	NP_609301.2	COesterase	41..565	CDD:278561	149/556 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440364
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.890