DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Glt

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	131/524 - (25%)
Similarity:	206/524 - (39%)	Gaps:	90/524 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LVQLPQ-GKLRGRD------NGSYYSYESIPYAEPPTGDLRFEAPEP--YKQKWSDIFDATKTPV 84
            :||.|: |::.|..      |....::..|.|.....|..||:|.:|  |:.:    .:||....
  Fly    61 VVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQPIGYQGR----VNATVQSP 121

  Fly    85 ACLQW---DQFTPGANKLVGEEDCLTVSVYKPKNSKRNSFPVVAHIHGGAFMFGAAWQNGHENVM 146
            .|.|:   |:.....::....:||||:.:|.|:.:  |..||:..:| |..:|....:....:.:
  Fly   122 NCAQFPELDRLRLSESRGENVDDCLTLDIYAPEGA--NQLPVLVFVH-GEMLFDGGSEEAQPDYV 183

  Fly   147 REGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAG 211
            .|...:||.|:|||.|.||:|....:||||..|.|.:|||:|:::|:..|||....|.|||.:.|
  Fly   184 LEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGG 248

  Fly   212 GASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVGC------ESAEDSTSL 270
            ....|...|....|.|.:.....||.||:|::|............|...|      .||:....|
  Fly   249 ATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLKPL 313

  Fly   271 KKCLKSKPASELVTAVRKFLI--------------------FSYVPFAPFSPVLEPSDAPDAII- 314
            ..||...|.|:||.|..:.|:                    ..::|..|.|.....|.|...||
  Fly   314 YDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNSSLALPMIIG 378

  Fly   315 -TQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFYRDT 378
             |:|....|           ||.:     |:....|:.|.....||             :..|.|
  Fly   379 ATKDASAFI-----------VSRI-----YDQLARLQSRNVSDYID-------------VVLRHT 414

  Fly   379 KTKKDMDDYSRKIKQEY---IGNQRFDIESYSE-LQRLFTDILFK----NSTQESLDLHRKYGKS 435
            ....:...:.:...:|.   |..|...:::.:. |..|...||::    ||..:|      |...
  Fly   415 APPSEHRLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQS------YRSV 473

  Fly   436 PAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFENFVRDVEMRPDEQIISRNFINMLAD 500
            |||.|.:|...|......|:|...:.......||...:|........:.|.::.:||..:.|..:
  Fly   474 PAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLNPLDRSLSRALVTMWVN 538

  Fly   501 FASS 504
            ||::
  Fly   539 FATT 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	131/524 (25%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	47/132 (36%)
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	131/524 (25%)
		Aes	<146..345	CDD:223730	63/201 (31%)
		RILP-like	<677..>717	CDD:304877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440349
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840