Protein Alignment Est-6 and Ces1e

DIOPT Version :9

• Sequence 1: NP_001261749.1
• Gene: Est-6 / 39392
• FlyBaseID: FBgn0000592
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_113753.2
• Gene: Ces1e / 29225
• RGDID: 621508
• Length: 561
• Species: Rattus norvegicus
• Alignment Length: 578
• Identity: 158/578 - (27%)
• Similarity: 247/578 - (42%)
• Gaps: 129/578 - (22%)

  Fly     8 LIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGRDNGSYYSYE----------SIPYAEPPTGDLR 62
            :::.|:....|.:.|...   :|...|||:.|:    |.|.|          .:|:|:||.|.||
  Rat     7 ILVFLAAFTAGGHPSSLP---VVDTLQGKVLGK----YVSLEGFTQPVAVFLGVPFAKPPLGSLR 64

  Fly    63 FEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVGE--------------EDCLTVSVYKP 113
            |..|:| .:.||.:.:.|..|..|.|    .|.|.::|.:              ||||.:::|.|
  Rat    65 FAPPQP-AEPWSFVKNTTSYPPMCSQ----DPVAGQIVNDLLTNREENISLQFSEDCLYLNIYTP 124

  Fly   114 KN-SKRNSFPVVAHIHGGAFMF-GAAWQNG-----HENVMREGKFILVKISYRLGPLGFVSTGDR 171
            .: :||:..||:..||||..:. ||:..:|     ||||      ::|.|.||||..||.||||.
  Rat   125 ADLTKRDRLPVMVWIHGGGLVLGGASTYDGLALSTHENV------VVVVIQYRLGIWGFFSTGDE 183

  Fly   172 DLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSG 236
            ...||:|..||..||.|::.||.:|||:|.:|.:.|.||||.||.:.:|......|...|.|.||
  Rat   184 HSRGNWGHLDQVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESG 248

  Fly   237 NALDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSY------- 294
            .||...:::|..|..|.::....||:|. .|.::..||:.|...||:....|..:||.
  Rat   249 VALTAGLVKKNTRPLAEKIAVVSGCKST-TSAAMVHCLRQKTEEELLETTLKLNLFSLDLHGDSR 312

  Fly   295 --VPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGY-------------- 343
              .||.|  .||:     ..::.:.|.:::....|..||:.|....::.|:
  Rat   313 QSYPFVP--TVLD-----GVVLPKMPEEILAEKDFNTVPYIVGINKQEFGWILPTMMNYPPSDMK 370

  Fly   344 ----NAALLLKERKSGIVIDDLNERWLELA--PYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFD 402
                .|..|||  ||..:: :|.|..:.:|  .||....|....||
  Rat   371 LDPMTATSLLK--KSSFLL-NLPEEAIPVAVEKYLRHTDDPDRNKD------------------- 413

  Fly   403 IESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRT---DYDFGT 464
                 :|..|..|::|   ...|:.:.|.:..:.|..|:|:.......:..:...|   |
  Rat   414 -----QLLELIGDVIF---GVPSVIVSRGHRDAGARTYMYEFQYRPSFSSKMKPSTVVGD----- 465

  Fly   465 VHGDDYFLIFENFVRDVEMRPDEQIISRNFINMLADFASSDN----GSLKYGECDFKD 518
             |||:.:.:|...:.......:|..:|:..:...|:||.:.|    |...:.|.|.|:
  Rat   466 -HGDEIYSVFGAPILRGGTSKEEINLSKMMMKFWANFARNGNPNGQGLPHWPEYDQKE 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	155/557 (28%)
		Aes	<110..>243	CDD:223730	59/139 (42%)
Ces1e	NP_113753.2	COesterase	24..545	CDD:278561	155/561 (28%)
		Aes	43..>239	CDD:223730	75/206 (36%)
		Prevents secretion from ER (Potential)	558..561

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010