DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Ces2i

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_008758816.2	Gene:	Ces2i / 292152	RGDID:	1565045	Length:	558	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	154/542 - (28%)
Similarity:	238/542 - (43%)	Gaps:	95/542 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRG-----RDNGS-YYSYESIPYAEPPTGDLR 62
            |..||:::|..:    :..|:..|:. ....|::||     :|..| .:::..||:|:||.|.|.
  Rat    13 VACGLLLLLQHV----HGQDSASPIR-NTQTGQVRGSFVHVKDTKSGVHTFLGIPFAKPPVGPLH 72

  Fly    63 F---EAPEPYKQKWSDIFDATKTPVACLQWDQF--------------TPGANKLVGEEDCLTVSV 110
            |   |.|||    ||.:.|.|..|..|||.|..              ||.:      ||||.:::
  Rat    73 FAPPEDPEP----WSGVRDGTSQPDMCLQTDIMKEDFIKEMKLTMHPTPMS------EDCLYLNI 127

  Fly   111 YKPKNSKRNS-FPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLP 174
            |.|.:::..| .||:..||||..:.|:|..|....:....:.::|.|.||||.|||.||||....
  Rat   128 YTPAHAREGSNLPVMVWIHGGGLVLGSASMNVASTLAATEEIVIVAIQYRLGILGFFSTGDEHAR 192

  Fly   175 GNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNAL 239
            ||:|..||..||.|::||||.|||....|.:.|.||||.||...::......|...|...||.||
  Rat   193 GNWGYLDQVAALCWVQQNIAYFGGNHGKVTIFGVSAGGTSVSSHVVSPMSKGLFHGAIMQSGVAL 257

  Fly   240 DPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVL 304
            .|.:|...:......:....||| |.||.:|.:||::|...|::...:.|.:...|....|.|
  Rat   258 LPDLISDTSEVVYKTVANLSGCE-ASDSEALIRCLRAKSKQEILAINQVFKMIPGVVDGKFLP-- 319

  Fly   305 EPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELA 369
                       :.|::::.||.|..||..:...|::.|....:.:.       :|.:.::
  Rat   320 -----------KHPQELLASGDFHPVPSIIGVNTDECGLGVPMFMG-------LDHIIKK----- 361

  Fly   370 PYLLFYRDT------KTKKDM---DDYSRKIKQEYIGNQRFDIESYSELQRLFT----DILFKNS 421
                ..|||      .|...|   .:....|.:||:|    |.|....||..|.    |.:|...
  Rat   362 ----ITRDTLPTVLKSTAAQMMLPPECIDLIMEEYMG----DTEDPETLQEQFKEMLGDFMFVIP 418

  Fly   422 TQESLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFENFV--RDVEMR 484
            ..|.  .|.:..::|.|.|.:.: ....|.||..:....|    ||||...:|.::.  .:.::.
  Rat   419 ALEV--AHFQRSQAPVYFYEFQH-LPSFIKQVRPSHVKAD----HGDDILFVFSSYFWGMNFDIT 476

  Fly   485 PDEQIISRNFINMLADFASSDN 506
            .:|:::.|..:...|:||.:.|
  Rat   477 EEEELLKRRVMKYWANFARNGN 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	148/517 (29%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	55/133 (41%)
Ces2i	XP_008758816.2	COesterase	30..537	CDD:395084	149/521 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940