DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Ces2g

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001099645.1	Gene:	Ces2g / 291952	RGDID:	1308358	Length:	560	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	154/551 - (27%)
Similarity:	237/551 - (43%)	Gaps:	92/551 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNYVGLGLIIVLSCLWLGSNASDTDDPLL---VQLPQGKL-RGRD-NGSYYSYESIPYAEPPTGD 60
            :|.|..||:::|  :.:....|....|:.   ....|||| ..:| ....:::..||:|:.|.|.
  Rat    10 LNAVLFGLLLLL--IHVQGQHSPESSPIRNTHTGQVQGKLTHSKDFKSGVHTFLGIPFAKAPVGP 72

  Fly    61 LRF---EAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANK--------LVGEEDCLTVSVYKPK 114
            |||   |||||    ||.:.|.|.....|.|..:......|        :...||||.:::|.|.
  Rat    73 LRFAPPEAPEP----WSGVRDGTSQSNICPQNVRMNMEGLKEMKLTLPPVSMSEDCLYLNIYAPA 133

  Fly   115 NSKRNS-FPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYG 178
            ::...| .||:..|||||...|.|.......:......::|.|.||||.|||.||||....||:|
  Rat   134 HAHEGSHLPVMVWIHGGALTVGMASMYDGSMLAATEDVVVVTIQYRLGVLGFFSTGDHHARGNWG 198

  Fly   179 LKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWV 243
            ..||..||:|::||||.|||.|..|.:.|.||||.||...::......|...|...||.||.|
  Rat   199 YLDQVAALRWVQQNIAHFGGNPDCVTIFGESAGGLSVSSHVVSPMSKGLFHRAIMESGVALMP-- 261

  Fly   244 IQKGARGRAFELGRNV--------GCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPF 300
                  |..|.....|        ||| |.|..||..||:.|...::....::|.:...|....|
  Rat   262 ------GTIFNFSEMVYQMVVKLSGCE-AMDPESLVHCLRGKSEEQITVISKEFQMIPAVVDGEF 319

  Fly   301 SPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKS--GIVIDDLNE 363
            .|             ..|::::.|..|..||..:.:..::.|:....::...::  ||..::|..
  Rat   320 LP-------------NHPQELLASADFHPVPSIIGFNNDEYGWIVPKVIGSAQTIKGITRENLQA 371

  Fly   364 RWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFT----DILFKNSTQE 424
            ...:.||.::.         ..:.|..:.:||:|    |||....||..||    |.:|...:.:
  Rat   372 FLKDTAPQMML---------PPECSDLLMEEYMG----DIEDPQTLQAQFTEMMEDFMFVIPSLQ 423

  Fly   425 SLDLHRKYGKSPAYAYVYDNPAE--KGI--AQVLANRTDYDFGTVHGDDYFLIFENFV--RDVEM 483
            .....|.:  :|.|.|.:.:.:.  |.|  ..|.|:         |||:...:|.:|.  ..:.:
  Rat   424 VARFQRSH--APVYFYEFQHQSSFLKDIRPPHVKAD---------HGDEVPFVFGSFFWGMKLNL 477

  Fly   484 RPDEQIISRNFINMLADFA---SSDNGSLKY 511
            ...|::::|..:...|:||   :.::.||.|
  Rat   478 TEGEKLLNRRMMKYWANFARYGNPNSNSLPY 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	147/523 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	56/133 (42%)
Ces2g	NP_001099645.1	COesterase	31..539	CDD:278561	148/528 (28%)
Ces2g	NP_001099645.1	Aes	<129..>232	CDD:223730	45/102 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336175
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840