Protein Alignment Est-6 and CES4A

DIOPT Version :9

• Sequence 1: NP_001261749.1
• Gene: Est-6 / 39392
• FlyBaseID: FBgn0000592
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 163/591 - (27%)
• Similarity: 251/591 - (42%)
• Gaps: 148/591 - (25%)

  Fly    51 IPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTP-------------VA----------------- 85
            :|::.||.|.|||..||| .:.|..|.|||..|             ||
Human    77 VPFSRPPLGILRFAPPEP-PEPWKGIRDATTYPPGWSLALSPGWSAVARSRLTATSASRVQASLL 140

  Fly    86 ----------CLQ--WDQFTPGANKLVG----------EEDCLTVSVYKPKNSKRN-SFPVVAHI 127
                      |||  |.|.   |:..|.          .||||.::||.|..:..: ..||:...
Human   141 PQPLSIWGYRCLQESWGQL---ASMYVSTRERYKWLRFSEDCLYLNVYAPARAPGDPQLPVMVWF 202

  Fly   128 HGGAFMFGAAWQ-NGHENVMREGKFILVKISYRLGPLGFV----STGDRDLPGNYGLKDQRLALK 187
            .||||:.|||.. .|.:...|| |.:||.:.:|||..||:    .|.|....||:||.||..||:
Human   203 PGGAFIVGAASSYEGSDLAARE-KVVLVFLQHRLGIFGFLRWRGRTDDSHARGNWGLLDQMAALR 266

  Fly   188 WIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRA 252
            |:::|||:|||:|.||.|.|.|||..|:...|:......|...|.|.||.||....|.......|
Human   267 WVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAISQSGTALFRLFITSNPLKVA 331

  Fly   253 FELGRNVGCESAEDSTS-LKKCLKSKPASELVTAVRKF----LIFSYVP---FAPFSPVLEPSDA 309
            .::....||.  .:||. |..||::...::::....|.    |.|...|   ....|||::
Human   332 KKVAHLAGCN--HNSTQILVNCLRALSGTKVMRVSNKMRFLQLNFQRDPEEIIWSMSPVVD---- 390

  Fly   310 PDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLF 374
             ..:|..||..::..||...||:.:.                      :::|...|  |.||::.
Human   391 -GVVIPDDPLVLLTQGKVSSVPYLLG----------------------VNNLEFNW--LLPYIMK 430

  Fly   375 Y--------RDTKTK-----KDMDDYSRK----IKQEYIGNQRFDIESYSELQRLFTDIL----F 418
            :        ::|.||     :.:.:.:::    :.:||:.|  .:...:..|:....||:    |
Human   431 FPLNRQAMRKETITKMLWSTRTLLNITKEQVPLVVEEYLDN--VNEHDWKMLRNRMMDIVQDATF 493

  Fly   419 KNSTQESLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDD-YFLIFENFVRDVE 482
            ..:|.::...||..| .|.|.|.:::.| :||  ::..|||   |..|||: |||....|...:.
Human   494 VYATLQTAHYHRDAG-LPVYLYEFEHHA-RGI--IVKPRTD---GADHGDEMYFLFGGPFATGLS 551

  Fly   483 MRPDEQIISRNFINMLADFASSDN---GSL----------KYGECDFKDNVGSE-KFQLLAIYID 533
            | ..|:.:|...:...|:||.:.|   |:|          ||.:.||...||.: |.:.:|.::.
Human   552 M-GKEKALSLQMMKYWANFARTGNPNDGNLPCWPRYNKDEKYLQLDFTTRVGMKLKEKKMAFWMS 615

  Fly   534 GCQNRQ 539
            ..|:::
Human   616 LYQSQR 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	162/587 (28%)
		Aes	<110..>243	CDD:223730	57/138 (41%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	162/581 (28%)
		Aes	<184..>291	CDD:223730	47/107 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142700
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840