DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and cest-9.2

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_741910.3	Gene:	cest-9.2 / 259729	WormBaseID:	WBGene00007695	Length:	617	Species:	Caenorhabditis elegans

Alignment Length:	557	Identity:	124/557 - (22%)
Similarity:	189/557 - (33%)	Gaps:	183/557 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LVQLPQGKLRG-----RDNGSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQ 88
            :::...|::||     .||...|.::|:|:|:||.|.||| ||..|...||.:.||:|...|||.
Worm    23 VIETSYGRVRGITEWSDDNNHKYMFKSVPFAKPPIGKLRF-APPQYPDSWSGVLDASKYSPACLS 86

  Fly    89 WDQFTPGANKLVGEEDCLTVSVYKPKNSKRNSFPVVAHIHGGAFMFGAAWQNGHENVMREGKFIL 153
            ....|....:.| .||||.::::..:...|:...|:.:.||||:       ||....|....|||
Worm    87 NSSTTSTPQEHV-SEDCLYINIFTSEKCLRSKCAVIVYFHGGAY-------NGDSATMFPDNFIL 143

  Fly   154 VKI----------SYRLGPLGFVSTGDRD-LPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVG 207
            .:.          ..|||..|.:..|... |..|..:.|...||.::...|.:|||:|:.|.::|
Worm   144 ERYVAEDVILAIPGVRLGVFGQLYFGPSALLTENLFMFDAVQALDFVHNEIPNFGGDPKQVTIMG 208

  Fly   208 HSAGGASVHLQMLREDFGQLARAAFSFSGNALDP------WVIQKGARG----------RAFELG 256
            ||:||..|.              |..|| |::||      .:|.....|          .:|.:.
Worm   209 HSSGGTLVE--------------ALGFS-NSVDPDLKLFQQIIVLSGTGMFGFYDLLVDNSFIIS 258

  Fly   257 RNVGC-----ESAEDST-----------------------------SLKKCLKSKPASELVTAVR 287
            ..:||     |...|:.                             :.|..|:..|..||...:.
Worm   259 EKLGCFNGTQEERTDANIAEILECMRQIDGHEIVGMQKHMEDVYKLTFKSLLRGAPFMELNGKIE 323

  Fly   288 KF------------------------LIFSYVPFAPF-SPVL-------EPSDAPDAIITQDPRD 320
            ||                        .::....|..| :||.       |.....|.:|..|...
Worm   324 KFRNSTSPRNAIFGTTEYEFRNEVERYLYITTTFLDFENPVAVAQHFDDELMQNMDTMINGDAVS 388

  Fly   321 VIKSGK---------------FGQVPWAVSYVTED--------------------GGYNAALLLK 350
            :..|..               |....|..|:...|                    ..:.:.||:.
Worm   389 IFVSAAAFSSAMANAGADVYLFETRQWPYSFHVSDMQYFIGIHREVLHTHDMDILDSFYSKLLVN 453

  Fly   351 ERKSGIVIDDLNERWLELAPYLLFYRDTKTKK------------------DMDDYSRKI----KQ 393
            ..|:|....:.|....|...||....||:..|                  ||.||.|.|    :.
Worm   454 FTKTGAPSPEWNSLEPEKMNYLELRVDTRNGKGPVMLEGYHDKEVSFWYGDMMDYDRNITKMRQS 518

  Fly   394 EYIGNQRFDIES----YSELQRLFTDILFKNSTQESL 426
            :.:..:...:||    :|.:....|.....|:|||::
Worm   519 KGLPRENQGVESQLKYWSSIVEPRTTAHANNATQENI 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	124/557 (22%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	40/149 (27%)
cest-9.2	NP_741910.3	Abhydrolase	19..501	CDD:304388	110/501 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157105
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740