DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and SPCC417.12

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_588289.2	Gene:	SPCC417.12 / 2539430	PomBaseID:	SPCC417.12	Length:	539	Species:	Schizosaccharomyces pombe

Alignment Length:	583	Identity:	132/583 - (22%)
Similarity:	220/583 - (37%)	Gaps:	150/583 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LGSNASDTDDPLLVQLP-QGKLRG----RDNG--SYYSYESIPYAEPPTGDLRFEAPEPYKQKWS 74
            |||.      |..:.:| .|.|.|    .:||  ..:.:..|.||:||.|.||:..|...:..:.
pombe     8 LGSK------PCTLNIPGMGVLHGLTVLDENGKEKCHRFTGIRYAKPPVGKLRWRRPVTLEDGYD 66

  Fly    75 DIFDATKTPVACLQWDQFTPGANKLVG---------EEDCLTVSVYKPKNSK-RNSFPVVAHIHG 129
            ...|..:....|.|     |..|....         :||||.::::.|...| ...:||:..|||
pombe    67 YSGDYNQFKTICPQ-----PFYNNRKNQVRNPDFKYDEDCLFLNIWVPAGEKPAEGWPVLYFIHG 126

  Fly   130 GAFMFGAAW---QNGHENVMREG---KFILVKISYRLGPLGFVSTGDRDL------PGNYGLKDQ 182
            |....|...   |...:::..:|   |||||...:||...||::  .::|      ..|:|..||
pombe   127 GWLQVGNPLHYRQCDPQDLQADGSPAKFILVSPGHRLNLFGFLA--GKELLEEDPKSSNFGFWDQ 189

  Fly   183 RLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDF----GQLARAAFSFS-GNALDPW 242
            ||.|:|..::|.||||..:|:.:.|.|||..|...|::.|.:    .|:.:.|...| |.::.|.
pombe   190 RLGLEWTYKHIESFGGNKENIAVGGISAGSYSALFQLIYETYHPEANQIIKRALLLSNGLSVQPK 254

  Fly   243 VIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLI--FSYVPFAPFSPVLE 305
            .::: ::.:..||.:..|......|....:.|::.|..:|...:....:  |..|....|   :.
pombe   255 SVEE-SQIQFNELAQKFGIPLELSSAEKLEKLRAIPFQDLADNILNLRLHTFRAVTDGDF---VN 315

  Fly   306 PSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSG--IVIDDLNERWLEL 368
            |:...|          |..|.||:                    :.|.||  ::|.::|...
pombe   316 PNTFKD----------IYDGTFGK--------------------RIRDSGRELIIGEVNNEH--- 347

  Fly   369 APYLLFYRDTKTKKDMDD--------YSRKI----------------KQEYI-------GNQRFD 402
                ..|.:|...|..:|        |..|:                ::||:       |:...|
pombe   348 ----SIYANTNPPKSKEDLFNQVNNYYPEKVTKALLELYPKVPDMEDEKEYLAAIKALFGSIVSD 408

  Fly   403 IESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAY-AYVYD--NPAEKGIAQVLANRTDYDFGT 464
            ::.|:.     |.:|.....:..:.|.:.|....|: ...:|  .|.|..:.
pombe   409 MQVYAS-----TRVLINGLVKGGVPLEKIYRYRIAFRGKFFDKYEPPESLVP------------- 455

  Fly   465 VHGDDYFLIFENFVRDVEMRPDEQIISRNFINMLADFAS---SDNGSLKYGECDFKDNVGSEK 524
             |..|..|.|.|.|..:  .|:|..|.:.::....::.|   :|.|:.|..|....|..|:.|
pombe   456 -HAGDLGLWFYNVVDGI--LPEEIPIYKAWLKSYGEWMSTGKTDWGTTKTEEYRLLDADGTIK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	128/571 (22%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	47/150 (31%)
SPCC417.12	NP_588289.2	PnbA	20..534	CDD:225181	127/565 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950