DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Ces2a

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	158/543 - (29%)
Similarity:	250/543 - (46%)	Gaps:	97/543 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRG-----RDNGS-YYSYESIPYAEPPTGDLR 62
            |..||:::|..:    :..|:..|:. ....|::||     :|..| .:::..||:|:||.|.||
  Rat    13 VACGLLLLLQHV----HGQDSASPIR-NTHTGQVRGSFVHVKDTKSGIHTFLGIPFAKPPVGPLR 72

  Fly    63 F---EAPEPYKQKWSDIFDATKTPVACLQWDQF--------------TPGANKLVGEEDCLTVSV 110
            |   |.|||    ||.:.|||..|..|||.|..              ||.:      ||||.:::
  Rat    73 FAPPEDPEP----WSGVRDATSQPAMCLQTDIMNLDGIKEMKLTVHPTPMS------EDCLYLNI 127

  Fly   111 YKPKNSKRNS-FPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLP 174
            |.|.:::..| .||:..||||..:.|:|..|....:....:.::|.|.||||.|||.||||::..
  Rat   128 YTPAHAREGSNLPVMVWIHGGGLVLGSASMNDASTLAATEEIVIVSIQYRLGVLGFFSTGDQNAR 192

  Fly   175 GNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNAL 239
            ||:|..||..||:|::||||.|||....|.:.|.||||.||...::......|...|...||.||
  Rat   193 GNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGVAL 257

  Fly   240 DPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVL 304
            .|.:|...:......:....||| |.||.:|.:||::|...|::...:.|.:...|....|.|
  Rat   258 LPDLISDKSEVVYKTVANLSGCE-APDSEALIRCLRAKSKQEILAINQVFKMIPGVVDGKFLP-- 319

  Fly   305 EPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGI--VIDDLNERWLE 367
                       :.|::::.||.|..||..:...|::.|:...:.|     |:  :|..:..   |
  Rat   320 -----------KHPQELLASGDFHPVPSIIGINTDECGWGIPVFL-----GLDHIIKKITR---E 365

  Fly   368 LAPYLLFYRDTKTKK-------DMDDYSRKIKQEYIGNQRFDIESYSELQRLFT----DILFKNS 421
            ..|.:|  :.|..:.       |:      |.:||:|    |.|:...||..|.    |.:|
  Rat   366 TLPTVL--KSTAAQMMLPPECIDL------IMEEYMG----DTENPETLQEQFRHMLGDFMF--- 415

  Fly   422 TQESLDL-HRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFENFV--RDVEM 483
            ...:|.: |.:..::|.|.|.:.: ....|.||..:....|    ||||...:|.:::  ...::
  Rat   416 VIPALQVAHFQRSQAPVYFYEFQH-LPSFIKQVRPSHVKAD----HGDDILFVFGSYLWGMTFDL 475

  Fly   484 RPDEQIISRNFINMLADFASSDN 506
            ..:|:::.|..:...|:||.:.|
  Rat   476 TEEEELLKRRVMKYWANFARTGN 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	152/518 (29%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	55/133 (41%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	153/522 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336167
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940