DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Nlgn3

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_766520.2	Gene:	Nlgn3 / 245537	MGIID:	2444609	Length:	825	Species:	Mus musculus

Alignment Length:	529	Identity:	149/529 - (28%)
Similarity:	217/529 - (41%)	Gaps:	93/529 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRG-------RDNGSYYSYESIPYAEPPTGDL 61
            ||..|.:.|..|.|...||.......|....|||||       ...|....|..:|||.||.|:.
Mouse    15 VGRSLCLTLGFLSLVLRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEK 79

  Fly    62 RFEAPEPYKQKWSDIFDATKTPVACLQ-------------WDQFTPGANKLV-----GEEDCLTV 108
            ||..||| ...||.|.:||..|..|.|             |  ||...:.:.     ..||||.:
Mouse    80 RFLPPEP-PPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVW--FTANLDIVATYIQEPNEDCLYL 141

  Fly   109 SVYKP----KNSKR-------------------NSFPVVAHIHGGAFMFGAAWQNGHENVMREGK 150
            :||.|    ..:|:                   .:.||:.:||||::|.|.........:...|.
Mouse   142 NVYVPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGN 206

  Fly   151 FILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASV 215
            .|::.::||:|.|||:||||:...|||||.||..||:|:.:|||.|||:|:.:.:.|...|.:.|
Mouse   207 VIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCV 271

  Fly   216 HLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPAS 280
            .|..|......|.:.|...||:||..|.:..........|...||| :..|:..:..||:.|.|.
Mouse   272 SLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGC-NVLDTVDMVDCLRQKSAK 335

  Fly   281 ELVTAVRKFLIFSYVP---FAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSY-----V 337
            |||..       ...|   ...|.||::....||     ||..:::.|:|      ::|     |
Mouse   336 ELVEQ-------DIQPARYHVAFGPVIDGDVIPD-----DPEILMEQGEF------LNYDIMLGV 382

  Fly   338 TEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIG-NQRF 401
            .:..|......:.:.:.|:...|.:.........|..|.:.|     |.....||..|.. ..|.
Mouse   383 NQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGK-----DTLRETIKFMYTDWADRD 442

  Fly   402 DIESYSE-LQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTV 465
            :.|:..: |..||||..:...:..:.|||.:|| ||.|.|.:.:..:..:....::       ..
Mouse   443 NPETRRKTLVALFTDHQWVEPSVVTADLHARYG-SPTYFYAFYHHCQSLMKPAWSD-------AA 499

  Fly   466 HGDDYFLIF 474
            |||:...:|
Mouse   500 HGDEVPYVF 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	141/504 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	52/155 (34%)
Nlgn3	NP_766520.2	COesterase	39..601	CDD:365897	141/505 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..172		1/20 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..668
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832430
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740