DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Ces1c

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_006255234.2	Gene:	Ces1c / 24346	RGDID:	2571	Length:	551	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	147/562 - (26%)
Similarity:	237/562 - (42%)	Gaps:	124/562 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LWLGSNASDTDDPLLVQLPQGKLRGRDNGSYYSYE----------SIPYAEPPTGDLRFEAPEPY 69
            :|...:.|   .|.:|...:||:.|:    |.|.|          .:|:|:||.|.|||..|||
  Rat    16 IWASGHPS---SPPVVDTTKGKVLGK----YVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPEP- 72

  Fly    70 KQKWSDIFDATKTPVACLQ--------WDQFTPGANKLVGE--EDCLTVSVYKPKNSKRNS-FPV 123
            .:.||.:.:.|..|..|.|        .|..:.|...:..|  ||||.:::|.|.:..:|| .||
  Rat    73 AEPWSFVKNTTTYPPMCSQDGVVGKLLADMLSTGKENIPLEFSEDCLYLNIYSPADLTKNSRLPV 137

  Fly   124 VAHIHGGAFMFGAAWQ------NGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQ 182
            :..||||..:.|.|..      :.||||      ::|.|.||||..|..||||....||:...||
  Rat   138 MVWIHGGGLIIGGASPYSGLALSAHENV------VVVTIQYRLGIWGLFSTGDEHSRGNWAHLDQ 196

  Fly   183 RLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKG 247
            ..||:|::.|||:|||.|.:|.:.|.||||.||.:.:|......|...|.|.||..|...:.:|.
  Rat   197 LAALRWVQDNIANFGGNPDSVTIFGESAGGVSVSVLVLSPLAKNLFHRAISESGVVLTTNLDKKN 261

  Fly   248 ARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDA 312
            .:..|..:....||.:. .|.::.:||:.|..:||:....|      :.....|.|::     ..
  Rat   262 TQAVAQMIATLSGCNNT-SSAAMVQCLRQKTEAELLELTVK------LDNTSMSTVID-----GV 314

  Fly   313 IITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDD--LNERWLELAPYLLFY 375
            ::.:.|.:::....|..||:.|.:..::.|:....::     |.::.:  :||:   :|..|| .
  Rat   315 VLPKTPEEILTEKSFNTVPYIVGFNKQEFGWIIPTMM-----GNLLSEGRMNEK---MASSLL-R 370

  Fly   376 RDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAY 440
            |.:......:.....|.::|:.......:....|..:|:|:.|
  Rat   371 RFSPNLNISESVIPAIIEKYLRGTDDPAKKKELLLDMFSDVFF---------------------- 413

  Fly   441 VYDNPAEKGIAQVLANRTDYDFG---------------------TV---HGDDYFLIFEN-FVRD 480
                    ||..||.:|:..|.|                     ||   |||:.|.:|.. |:::
  Rat   414 --------GIPAVLMSRSLRDAGAPTYMYEFQYRPSFVSDQRPQTVQGDHGDEIFSVFGTPFLKE 470

  Fly   481 VEMRPDEQIISRNFINMLADFASSDN----GSLKYGECDFKD 518
             ....:|..:|:..:...|:||.:.|    |...:.|.|.|:
  Rat   471 -GASEEETNLSKLVMKFWANFARNGNPNGEGLPHWPEYDQKE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	144/548 (26%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	56/139 (40%)
Ces1c	XP_006255234.2	COesterase	24..534	CDD:395084	145/551 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.000