DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Est-6 and CES3

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_079198.2	Gene:	CES3 / 23491	HGNCID:	1865	Length:	571	Species:	Homo sapiens

Alignment Length:	544	Identity:	137/544 - (25%)
Similarity:	227/544 - (41%)	Gaps:	81/544 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GLIIVLSCLWLGSNASDTDDPLL---VQLPQGKLRGRDNGSYYS------YESIPYAEPPTGDLR 62
            |:::.:.||.|...|:.|...:.   |....|::|||..|...:      :..||:|:||.|..|
Human    10 GVLVGVVCLLLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDR 74

  Fly    63 FEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLV--GE-------EDCLTVSVYKPKNSKR 118
            |.||.| .|.|..:.||:..|..||| |..:..:::.|  |:       ||||.::||.|.....
Human    75 FSAPHP-AQPWEGVRDASTAPPMCLQ-DVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPA 137

  Fly   119 NS-FPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQ 182
            .| .||:..:||||.:.|||.......:...|..::|.:.||||.|||.||||...|||.|..|.
Human   138 GSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDV 202

  Fly   183 RLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKG 247
            ..||:|:::|||.|||:...|.:.|.||||:.:...:|......|...|.:.||....|.:|...
Human   203 VAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSH 267

  Fly   248 ARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDA 312
            ....|.::...:.|.|:..: .:.:||:.|...|||.:.:            ....:.|......
Human   268 PWPLAQKIANTLACSSSSPA-EMVQCLQQKEGEELVLSKK------------LKNTIYPLTVDGT 319

  Fly   313 IITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPY---LLF 374
            :..:.|::::|...|..||:.:       |.|                 |..:..|.|.   ||.
Human   320 VFPKSPKELLKEKPFHSVPFLM-------GVN-----------------NHEFSWLIPRGWGLLD 360

  Fly   375 YRDTKTKKDM--------------DDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQES 425
            ..:..:::||              .:....:..||:|:.. |.::..:..:.|...:|.|....|
Human   361 TMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLGSNS-DAQAKCQAFQEFMGDVFINVPTVS 424

  Fly   426 LDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGT----VHGDDYFLIFENFVRDVEMRPD 486
            ...:.:...||.:.|.:.: .....|::.......|.|.    |.|..:.:...:.:...|...:
Human   425 FSRYLRDSGSPVFFYEFQH-RPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEE 488

  Fly   487 EQIISRNFINMLADFASSDNGSLK 510
            |:.:|...:.....||.:.:.:.|
Human   489 EKQLSLTMMAQWTHFARTGDPNSK 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	131/522 (25%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	52/133 (39%)
CES3	NP_079198.2	COesterase	32..547	CDD:278561	131/522 (25%)
		Aes	<129..>247	CDD:223730	47/117 (40%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142612
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840