Protein Alignment Est-6 and Ces4a

DIOPT Version :10

• Sequence 1: NP_788500.1
• Gene: Est-6 / 39392
• FlyBaseID: FBgn0000592
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_666325.2
• Gene: Ces4a / 234677
• MGIID: 2384581
• Length: 563
• Species: Mus musculus
• Alignment Length: 566
• Identity: 168/566 - (29%)
• Similarity: 251/566 - (44%)
• Gaps: 84/566 - (14%)

  Fly     6 LGLIIVLSCLWLGS--NASDTDDPLLVQLPQGKLRGRD----NGSYYSYESIPYAEPPTGDLRFE 64
            |||.:.| ||.:.:  .|..|.:|||: ...|.|:|:.    :.....:..||:::||.|..||.
Mouse    12 LGLSLTL-CLVVQTALGALHTKEPLLI-TKHGILQGKQVHVGDTPIQVFLGIPFSKPPVGTRRFA 74

  Fly    65 APEPYKQKWSDIFDATKTPVACLQ--WDQF------TPGANK-LVGEEDCLTVSVYKPKNSK-RN 119
            .||| ...|:.|.|||..|.:|||  |.|.      |....| |...||||.::||.|..:. ..
Mouse    75 PPEP-PLPWNGIRDATTYPPSCLQESWGQILSMYLNTRKQYKWLHFSEDCLYLNVYAPVLAPGAP 138

  Fly   120 SFPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRL 184
            ..||:....||||:.|:|.......:...||.:||.:.||||.|||.|||:....||:||.||..
Mouse   139 LLPVMVWFPGGAFLAGSASTYEGSELAARGKVVLVFLQYRLGILGFFSTGNSHARGNWGLLDQIA 203

  Fly   185 ALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGAR 249
            ||:|:::||.:|||:|.:|.|.|.|||..||...|:......|...|.|.||.|:....|.....
Mouse   204 ALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLMVSPLAQGLFHQAISQSGTAVLKAFITPDPL 268

  Fly   250 GRAFELGRNVGCESAEDSTS-LKKCLKSKPASELVTAVRKFLIF----------SYVPFAPFSPV 303
            ..|.::....||:  .:||. :.:||:|..|.| ||.|.|.:.|          ..|.|  .|||
Mouse   269 TSAKKIAHLAGCD--HNSTKVMVECLRSLSAEE-VTLVSKRMSFFQANSHKDPKEIVWF--LSPV 328

  Fly   304 LEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLE- 367
            ::     ..:..:||..::..|:...||:.:.....:..:|...|:|.:        ||:|.:.
Mouse   329 VD-----GVVFPEDPVVLLTRGQVKPVPYLLGVNNAEFEWNLPFLMKIQ--------LNQRMMNQ 380

  Fly   368 ------LAPYLLFYRDTKTKKDMDDYSRKIKQEYIGN--QRFDIESY-SELQRLFTDILFKNSTQ 423
                  |..:.:....||.:..:      :.:||:.:  ...|.:.: :.|..|..|..|..:|.
Mouse   381 TNINKILWSFNVLLNITKEQVPV------VAREYLNDAISNHDWKMFRNRLIDLIGDATFVYATL 439

  Fly   424 ESLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFENFVRDVEMRPDEQ 488
            ::...||..| ||.|.|.:.:.|..||.....|..|      |||:...:|.:.........:|:
Mouse   440 QAARYHRDAG-SPVYLYEFKHHASSGIIIKPYNGAD------HGDELSYLFGSPFSKGSSAGEEK 497

  Fly   489 IISRNFINMLADFASSDNGS-------------LKYGECDFKDNVG 521
            ..|...:...|:||.:.|.:             .||.:.||...||
Mouse   498 EFSLQMMKYWANFAHTGNPNGEKLPYWPRFDKDEKYLQLDFDTRVG 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_788500.1	Esterase_lipase	29..537	CDD:238191	158/541 (29%)
Ces4a	NP_666325.2	COesterase	33..554	CDD:395084	160/544 (29%)