DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Ces2e

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001157228.1	Gene:	Ces2e / 234673	MGIID:	2443170	Length:	559	Species:	Mus musculus

Alignment Length:	568	Identity:	154/568 - (27%)
Similarity:	251/568 - (44%)	Gaps:	97/568 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNYVGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRG-----RDNG-SYYSYESIPYAEPPTG 59
            :|.|..|:::::    |.....|:..|:. ....|::||     :|.. :.:::..||:|:||.|
Mouse    10 LNAVACGVLLLV----LHVQGQDSASPIR-NTHTGQVRGSLVHVKDTDIAVHTFLGIPFAKPPVG 69

  Fly    60 DLRF---EAPEPYKQKWSDIFDATKTPVACLQWDQFTPGAN-KLVG--------EEDCLTVSVYK 112
            .|||   |||||    ||.:.|.|..|..|||.|......: |::.        .||||.:::|.
Mouse    70 PLRFAPPEAPEP----WSGVRDGTSHPNMCLQNDNLMGSEDLKMMNLILPPISMSEDCLYLNIYV 130

  Fly   113 PKNSKRNS-FPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGN 176
            |.::...| .||:..|||||...|.|.......:......::|.|.||||.|||.||||:...||
Mouse   131 PAHAHEGSNLPVMVWIHGGALTVGMASMYDGSMLAATEDVVVVAIQYRLGVLGFFSTGDQHAKGN 195

  Fly   177 YGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDP 241
            :|..||..||:|::|||..|||.|..|.:.|.||||.||...::......|...|...||.|:.|
Mouse   196 WGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVAVLP 260

  Fly   242 WVIQKGARGRAFELGRNV-GCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLE 305
            .:|...:. ....:..|: || :|.:|.:|..||:.|..:|::...:.|.|...|....|.|
Mouse   261 DLISSSSE-MVHRIVANLSGC-AAVNSETLMCCLRGKNEAEMLAINKVFKIIPGVVDGEFLP--- 320

  Fly   306 PSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAP 370
                      :.|::::.|..|..||..:....::.|:....::...:.   |:::..:.|   |
Mouse   321 ----------KHPQELMASKDFHPVPSIIGINNDEYGWILPTIMDPAQK---IEEITRKTL---P 369

  Fly   371 YLLFYRDTKTKKDM-DDYSRKIKQEYIGNQRFDIESYSELQRLFT----DILFKNSTQESLDLHR 430
            .:|  :.|..|..: .:....:.:||:|    |.|....||..|.    |.:|.....:.....|
Mouse   370 AVL--KSTALKMMLPPECGDLLMEEYMG----DTEDPETLQAQFREMKGDFMFVIPALQVAHFQR 428

  Fly   431 KYGKSPAYAYVYDNPAEKGIAQVLANRTDY--DF-----GTVHGDDYFLIFENFVRDVEM--RPD 486
            .:  :|.|.|.:.            :|..:  ||     ...|||:.||:|.....::::  ..:
Mouse   429 SH--APVYFYEFQ------------HRPSFFKDFRPPYVKADHGDEIFLVFGYQFGNIKLPYTEE 479

  Fly   487 EQIISRNFINMLADFASSDNGSL-------------KYGECDFKDNVG 521
            |:.:||..:...|:||...|.:.             :|.:.|.:.:||
Mouse   480 EEQLSRRIMKYWANFARHGNPNSEGLPYWPVMDHDEQYLQLDIQPSVG 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	148/540 (27%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	54/133 (41%)
Ces2e	NP_001157228.1	COesterase	30..538	CDD:278561	149/544 (27%)
Ces2e	NP_001157228.1	Aes	<128..>231	CDD:223730	44/102 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832646
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840