DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Est-6 and Ces2c

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_663578.1	Gene:	Ces2c / 234671	MGIID:	2385905	Length:	561	Species:	Mus musculus

Alignment Length:	505	Identity:	149/505 - (29%)
Similarity:	240/505 - (47%)	Gaps:	77/505 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GKLRG-----RD-NGSYYSYESIPYAEPPTGDLRF---EAPEPYKQKWSDIFDATKTPVACLQ-W 89
            |:::|     :| ....:::..||:|:||.|.|||   |||||    ||.:.|.|..|..||| .
Mouse    41 GQIQGSLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEP----WSGVRDGTAHPAMCLQNL 101

  Fly    90 DQFT----PGANKLVG----EEDCLTVSVYKPKNSKRNS-FPVVAHIHGGAFMFG-AAWQNGHEN 144
            |...    |....::.    .||||.:::|.|.::...| .||:..|||||.:.| |:..:|...
Mouse   102 DMLNEAGLPDMKMMLSSFPMSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGALVIGMASMFDGSLL 166

  Fly   145 VMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHS 209
            .:.| ..::|.|.||||.|||.||||:...||:|..||..||:|::||||.|||.|..|.:.|.|
Mouse   167 TVNE-DLVVVTIQYRLGVLGFFSTGDQHARGNWGYLDQAAALRWVQQNIAHFGGNPDRVTIFGES 230

  Fly   210 AGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCL 274
            |||.||...::......|...|...||.||.|.:|.:.:...:..:.:..||| |.||.:|.:||
Mouse   231 AGGTSVSSHVVSPMSQGLFHGAIMESGVALLPDLISETSEMVSTTVAKLSGCE-AMDSQALVRCL 294

  Fly   275 KSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTE 339
            :.|..:|:: |:.|  :|..:|     .|::....|     :.|::::.|..|..||..:....:
Mouse   295 RGKSEAEIL-AINK--VFKMIP-----AVVDGEFFP-----RHPKELLASEDFHPVPSIIGVNND 346

  Fly   340 DGGYNAALLLKERK--SGIVIDDLNERWLELAPYLLFYRDTKTKKDM-DDYSRKIKQEYIGNQRF 401
            :.|::..:::...:  .||..::|.          ...:||..:..: .:.|..:.:||:|
Mouse   347 EFGWSIPVVMGSAQMIKGITRENLQ----------AVLKDTAVQMMLPPECSDLLMEEYMG---- 397

  Fly   402 DIESYSELQRLFT----DILFKNSTQESLDLHRKYGKSPAYAYVYDNPAE--KGI--AQVLANRT 458
            |.|....||..||    |.:|.....:.....|.:  :|.|.|.:.:|..  |.:  ..|.|:
Mouse   398 DTEDAQTLQIQFTEMMGDFMFVIPALQVAHFQRSH--APVYFYEFQHPPSYFKDVRPPHVKAD-- 458

  Fly   459 DYDFGTVHGDDYFLIFENFV--RDVEMRPDEQIISRNFINMLADFASSDN 506
                   |.|:...:|.:|.  ..::...:|:::||..:...|:||...|
Mouse   459 -------HADEIPFVFASFFWGMKLDFTEEEELLSRRMMKYWANFARHGN 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	149/505 (30%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	58/134 (43%)
Ces2c	NP_663578.1	COesterase	31..540	CDD:278561	149/505 (30%)
		Aes	<130..>233	CDD:223730	47/103 (46%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840