DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Ces2b

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_937814.1	Gene:	Ces2b / 234669	MGIID:	2448547	Length:	556	Species:	Mus musculus

Alignment Length:	535	Identity:	148/535 - (27%)
Similarity:	238/535 - (44%)	Gaps:	87/535 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IIVLSCLWLGSNASDTDDPLLVQLPQ---GKLRG-----RD-NGSYYSYESIPYAEPPTGDLRF- 63
            :::...|.|..:....|.|....:..   |::||     :| ....:::..||:|:||.|.|||
Mouse    12 VLLFGLLLLLGHVQGQDSPEASPIRNTHTGQVRGSLVHVKDTKAGVHTFLGIPFAKPPVGPLRFA 76

  Fly    64 --EAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLV--------GEEDCLTVSVYKPKNSKR 118
              |||||    ||.:.|.|..|..|||    ..|..|.:        ..||||.:::|.|.::..
Mouse    77 PPEAPEP----WSGVRDGTAHPAMCLQ----NLGVMKEIKLKLPPVSTSEDCLYLNIYTPAHAHE 133

  Fly   119 NS-FPVVAHIHGGAFMFGAAWQNGHENVMREGK-------FILVKISYRLGPLGFVSTGDRDLPG 175
            .| .||:..||||..:.|.|       .|.:|.       .::|.|.||||.|||.||||:...|
Mouse   134 GSNLPVMVWIHGGGLVAGMA-------SMYDGSLLAAIEDLVVVTIQYRLGVLGFFSTGDQHARG 191

  Fly   176 NYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALD 240
            |:|..||..||:||:||||.|||:|..|.:.|.||||.||...::......|...|...||.||.
Mouse   192 NWGFLDQVAALRWIQQNIAHFGGKPDRVTIFGESAGGTSVSSHVVSPMSKGLFHGAIMESGVALL 256

  Fly   241 PWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLE 305
            |::|...:...:..:.:..||| |.||.:|.:||:.|..:|:: |:.|.:            .:.
Mouse   257 PYLITDTSEMVSTTVAKLSGCE-AMDSEALVRCLRGKSEAEIL-AINKLV------------QMI 307

  Fly   306 PSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAP 370
            |:........:.|::::.|..|..||..:....::.|:...:::   .|...|.::....|:..
Mouse   308 PAVVDGEFFPRHPKELLASEDFHPVPSIIGVNNDEFGWTIPVVM---GSAQTIKEITRENLQAV- 368

  Fly   371 YLLFYRDTKTKKDM-DDYSRKIKQEYIGNQRFDIESYSELQRLFT----DILFKNSTQESLDLHR 430
                .::|..:..: .:.|..:.:||:|    |.|....||..||    |.:|.....:.....|
Mouse   369 ----LKNTTAQLMLPPECSDLLMEEYMG----DTEDAQTLQIQFTEMMEDFMFVIPALQVAYFQR 425

  Fly   431 KYGKSPAYAYVYDNPAEKGI--AQVLANRTDYDFGTVHGDDYFLIFENFVRDVEM--RPDEQIIS 491
            .:.....|.:.:...:.|.:  ..|.|:         |.|:...:|..|..|:::  ...|:::|
Mouse   426 SHASVYFYEFQHQIASLKDVRPTHVKAD---------HADEIPFVFGYFFWDMKLDFTEGEKLLS 481

  Fly   492 RNFINMLADFASSDN 506
            |..:...|:||...|
Mouse   482 RRMMKYWANFARHGN 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	144/515 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	58/140 (41%)
Ces2b	NP_937814.1	COesterase	34..535	CDD:365897	144/513 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832648
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840