DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and NLGN4Y

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001352513.1	Gene:	NLGN4Y / 22829	HGNCID:	15529	Length:	836	Species:	Homo sapiens

Alignment Length:	565	Identity:	158/565 - (27%)
Similarity:	236/565 - (41%)	Gaps:	118/565 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LGLIIVLSCLWLGSNA---------------SDTDDPLLVQLPQGKLRGRDN-------GSYYSY 48
            |.|:....|:.|.||.               |....| :|....||::|...       |....|
Human    10 LPLLFTSVCVMLNSNVLLWITALAIKFTLIDSQAQYP-VVNTNYGKIQGLRTPLPSEILGPVEQY 73

  Fly    49 ESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQ--------------WDQFTPGANKL 99
            ..:|||.||||:.||:.||. ...|:.|.:||:....|.|              |  ||...:.|
Human    74 LGVPYASPPTGERRFQPPES-PSSWTGIRNATQFSAVCPQHLDERFLLHDMLPIW--FTTSLDTL 135

  Fly   100 V-----GEEDCLTVSVYKP----KNSKRNS--------------------FPVVAHIHGGAFMFG 135
            :     ..||||.:::|.|    .|.|||:                    .||:.:||||::|.|
Human   136 MTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSNDHGEDKDIHEQNSKKPVMVYIHGGSYMEG 200

  Fly   136 AAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEP 200
            .........:...|..|::.|:||||.|||:||||:...|||||.||..||:||::|:.:|||:|
Human   201 TGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDP 265

  Fly   201 QNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVGCESAE 265
            :.|.:.|..||.:.|.|..|......|.:.|...||.||..|.:..........|...|||...
Human   266 KRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNML- 329

  Fly   266 DSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQV 330
            |:|.:.:|||:|...||:...    |........|.||::....||     ||:.:::.|:|
Human   330 DTTDMVECLKNKNYKELIQQT----ITPATYHIAFGPVIDGDVIPD-----DPQILMEQGEF--- 382

  Fly   331 PWAVSY-----VTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFY---RDT--KTKKDM- 384
               ::|     |.:..|......:.:.:.|:..:|.:.........|..|   :||  :|.|.|
Human   383 ---LNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMY 444

  Fly   385 DDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEKG 449
            .|::.|...|   .:|      ..|..||||..:......:.|||.:|| ||.|.|.:.:..:..
Human   445 TDWADKENPE---TRR------KTLVALFTDHQWVAPAVATADLHAQYG-SPTYFYAFYHHCQSE 499

  Fly   450 IAQVLANRTDYDFGTVHGDDYFLIFENFVRDVEMRPDEQIISRNF 494
            :....|:       :.|||:...:|     .:.|....::.|.||
Human   500 MKPSWAD-------SAHGDEVPYVF-----GIPMIGPTELFSCNF 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	150/527 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	57/156 (37%)
NLGN4Y	NP_001352513.1	COesterase	46..610	CDD:306613	151/529 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142709
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840