DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and CES5A

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001177087.1	Gene:	CES5A / 221223	HGNCID:	26459	Length:	604	Species:	Homo sapiens

Alignment Length:	486	Identity:	136/486 - (27%)
Similarity:	215/486 - (44%)	Gaps:	75/486 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 IPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQ---W---DQFTPGAN--KLVGEEDCLT 107
            :|:|.||.|.|||..|:| ...|.::.:||..|..|||   |   ||.....:  |....||||.
Human    89 VPFAAPPLGSLRFTNPQP-ASPWDNLREATSYPNLCLQNSEWLLLDQHMLKVHYPKFGVSEDCLY 152

  Fly   108 VSVYKPKNSKRNS-FPVVAHIHGGAFMFGAA------WQNGHENVMREGKFILVKISYRLGPLGF 165
            :::|.|.::...| .||:....||||..|:|      ....:|:|      ::|.:.||||..||
Human   153 LNIYAPAHADTGSKLPVLVWFPGGAFKTGSASIFDGSALAAYEDV------LVVVVQYRLGIFGF 211

  Fly   166 VSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARA 230
            .:|.|:..|||:..|||..||.|:::||..|||:|.:|.:.|.|||..||...:|......|...
Human   212 FTTWDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILSPMAKGLFHK 276

  Fly   231 AFSFSGNALDPWVIQKGARGRAFELGRNVG-----C-ESAEDSTSLKKCLKSKPASELVTAVRKF 289
            |...||.|:.|::     ....:|...::.     | .:|.||.:|.:||::||:.||:|..:|.
Human   277 AIMESGVAIIPYL-----EAHDYEKSEDLQVVAHFCGNNASDSEALLRCLRTKPSKELLTLSQKT 336

  Fly   290 LIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKS 354
            ..|:.|....|.|             .:|.|::....|..:|..:.....:.|:    ||..:::
Human   337 KSFTRVVDGAFFP-------------NEPLDLLSQKAFKAIPSIIGVNNHECGF----LLPMKEA 384

  Fly   355 GIVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFK 419
            ..::...|:   .||.:|:    .........|...:..||..::....|....|..|..|:.|.
Human   385 PEILSGSNK---SLALHLI----QNILHIPPQYLHLVANEYFHDKHSLTEIRDSLLDLLGDVFFV 442

  Fly   420 NSTQESLDLHRKYGKSPAYAYVYDNP----AEKGIAQVLANRTD---YDFG--TVHGDDYFLIFE 475
            .....:...||..| :|.|.|.:.:.    .:...|.|.|:..|   :.||  .:.||  .::||
Human   443 VPALITARYHRDAG-APVYFYEFRHRPQCFEDTKPAFVKADHADEVRFVFGGAFLKGD--IVMFE 504

  Fly   476 NFVRDVEMRPDEQIISRNFINMLADFASSDN 506
            ....      :|:::||..:...|.||.:.|
Human   505 GATE------EEKLLSRKMMKYWATFARTGN 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	136/486 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	51/139 (37%)
CES5A	NP_001177087.1	COesterase	56..568	CDD:278561	136/486 (28%)
CES5A	NP_001177087.1	Aes	<155..>258	CDD:223730	41/108 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142590
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840