DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Ces2e

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	152/536 - (28%)
Similarity:	231/536 - (43%)	Gaps:	78/536 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNYVGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRG-----RDNGS-YYSYESIPYAEPPTG 59
            :|.|..||:: |.|...|   .|:..|:. ....|::||     :|..| .:::..||:|:||.|
  Rat    10 LNAVVWGLLL-LFCQVQG---QDSASPIR-NTHTGQVRGSFVHVKDTKSGVHTFLGIPFAKPPIG 69

  Fly    60 DLRFEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGAN-----------KLVGEEDCLTVSVYKP 113
            .|||..||| .:.||.:.|.|..|..||   |...|.|           .:...||||.:|:|.|
  Rat    70 PLRFAPPEP-PEPWSGVRDGTSHPAMCL---QNIDGLNLENLKIKMSRSPVSMSEDCLYLSIYTP 130

  Fly   114 KNSKRNS-FPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNY 177
            .::.::| .||:..||||...:|.|.......:......::|.|.||||.|||.||||....||:
  Rat   131 AHTHKDSNLPVMVWIHGGGLCWGMASTYDGSMLAAIEDVVVVTIQYRLGILGFFSTGDEHARGNW 195

  Fly   178 GLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPW 242
            |..||..||:|::|||..|||.|..|.:.|.||||.||...::......|...|...||.||.|.
  Rat   196 GYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVALLPN 260

  Fly   243 VIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPS 307
            :|...:......:....|||.. ||.:|..||:.|...|::.........|.|....|.|
  Rat   261 LISNTSEVIYTMVANLSGCEPV-DSEALMSCLREKSEEEMLAINNIVRTISGVVDGKFLP----- 319

  Fly   308 DAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYL 372
                    :.|.:::.|..|..||..:...:::.|:...:|..:.    .:.::|...:...
  Rat   320 --------RHPLELLASVDFHPVPSIIGINSDEYGWIIPMLHPDS----TMKEINRETMRAV--- 369

  Fly   373 LFYRDTKTKKDM-DDYSRKIKQEYIGNQRFDIESYSELQRLFT----DILFKNSTQESLDLHRKY 432
              .::|..:..: .:.|..:.:||:|    |.|....||..|.    |.:|.....:.....|.:
  Rat   370 --LKNTAVQMMLPPECSDLLMEEYMG----DTEDSKTLQIQFNEMMGDFIFVIPALQVAHFQRSH 428

  Fly   433 GKSPAYAYVYDNPAE--KGI--AQVLANRTD---YDFGTVHGDDYFLIFENFVRDVEMRPDEQII 490
              :|.|.|.:.:.:.  |.|  ..|.|:..|   |..|.:..|..|:..|          :|:::
  Rat   429 --APVYFYEFQHQSNFLKDIRPPHVKADHGDELPYVIGYLFWDMKFVFTE----------EEKLL 481

  Fly   491 SRNFINMLADFASSDN 506
            ||..|...|:||...|
  Rat   482 SRKMIKYWANFARHGN 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	143/508 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	54/133 (41%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	144/512 (28%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	43/102 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336177
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840