Protein Alignment Est-6 and cest-30

DIOPT Version :9

• Sequence 1: NP_001261749.1
• Gene: Est-6 / 39392
• FlyBaseID: FBgn0000592
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_504407.1
• Gene: cest-30 / 181871
• WormBaseID: WBGene00015071
• Length: 578
• Species: Caenorhabditis elegans
• Alignment Length: 617
• Identity: 161/617 - (26%)
• Similarity: 261/617 - (42%)
• Gaps: 157/617 - (25%)

  Fly     3 YVGLGLIIVLSCLWLG--SNASDTDDPLLVQLPQGKLRG----RDNGSYY--SYESIPYAEPPTG 59
            |.|:|.:: ||.:..|  .|.:...:..::..|.|.:||    ..||:..  .|..||:|:.|.|
 Worm     6 YWGIGCLL-LSIVEGGFLVNLTPEKNSQILNAPCGPIRGNIYKHKNGTKIVDGYLGIPFAKAPVG 69

  Fly    60 DLRFEAPEPYKQKWSDIFDATKTPVACLQWDQF---TPGANKLVGEEDCLTVSVYKPKNSKRNSF 121
            .|:|:.|.. .:||::..|..:....|.|..:|   |..:.....||:|||::|:.|: .|...|
 Worm    70 ALKFKKPVA-AEKWTEPRDCYEYGPGCPQTGRFAALTAKSTAAFAEENCLTLNVFAPR-WKLAEF 132

  Fly   122 ----PVVAHIHGGAFMFG-AAWQNGHE--NVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGL 179
                ||:.:|:||.:..| .::.:.:.  ..:.....|:|.::||||||||::..|....|||||
 Worm   133 PKGLPVLVYIYGGGYEIGFTSYMDDYSLTGTLPLKDVIVVTMNYRLGPLGFLTIADGIANGNYGL 197

  Fly   180 KDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVI 244
            .||.|||:|::.|||||||.|::|.|.|.|||..|.....|.....||.:.:.|.||.|...:.|
 Worm   198 WDQTLALQWVQDNIASFGGNPESVTLSGTSAGATSTDFLSLSPHSNQLFQRSISMSGTAFCNFAI 262

  Fly   245 QKGARGRAFELGRNVGCESAE-------DSTSLKKCLKSKPASEL-------VTAVRKFLIFSYV 295
                |.:..|:|  |..|.|:       ||.||.....::..|:.       .||.      ..|
 Worm   263 ----RPKDVEVG--VCKEFAQFQGYTGTDSQSLFDWYMAQNVSKFKEVAGFQSTAA------GAV 315

  Fly   296 PFAP-----FSPVLEPSD-----AP--DAIITQDPRDVIKSGKFGQV---P-WAVSYVTEDGGYN 344
            ||.|     |.|  :|.|     ||  ||:||     |:.....|.:   | :|.:|...:|
 Worm   316 PFIPNFDGDFFP--KPFDILRREAPKKDALIT-----VVTMESVGMIIFNPLFANAYNNFEG--- 370

  Fly   345 AALLLKERKSGIVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSEL 409
                           .:||.:   .|            |:.||...:|::..|....|:.:..:.
 Worm   371 ---------------FINETY---GP------------DVTDYYADVKKKLTGFYLKDVNASDKA 405

  Fly   410 ---QRL---FTDILFKNSTQESLDLHRKYGKSPAY--AYVYDNPAEKGIAQVL------ANRTDY 460
               :|:   .:|.:|.:.|.:::..:.||| :..|  ::.|.|.|.|.:.:::      ::.:|:
 Worm   406 TVNRRVVDYVSDSVFNSGTLDAVKSYVKYG-NKVYLGSFNYFNDATKDMVELMQPFKEASHSSDF 469

  Fly   461 DFGTVHGDDYF--LIFENFV---RDVEMRPDEQIISRNFINMLADFASSDNG------------- 507
            .:       ||  .:..||.   .::|:......:..||:..     ...||
 Worm   470 KY-------YFGSGVMANFTPTDEEMEVMDMSGTLMANFVKY-----GDPNGKSGTKPWKPYTIL 522

  Fly   508 ------SLKYGECDFKDNVGSEKFQLLAIYID 533
                  .:.|..|:..||..:.:   |.||.|
 Worm   523 KPNMYYKIDYPTCEMSDNFQNGR---LRIYDD 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	154/589 (26%)
		Aes	<110..>243	CDD:223730	54/139 (39%)
cest-30	NP_504407.1	COesterase	31..539	CDD:278561	148/574 (26%)
		Aes	<122..>230	CDD:223730	45/108 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157206
Domainoid	1	1.000	183	1.000	Domainoid score	I2040
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	183	1.000	Inparanoid score	I2624
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790