DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and cest-19

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_509187.4	Gene:	cest-19 / 180973	WormBaseID:	WBGene00020125	Length:	607	Species:	Caenorhabditis elegans

Alignment Length:	530	Identity:	154/530 - (29%)
Similarity:	235/530 - (44%)	Gaps:	84/530 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LWLGSNASDTD---DPLLVQLPQGKLRGR----DNGSYYSYESIPYAEPPTGDLRFEAP-EPYKQ 71
            ||..|:.:.:.   .|..:::..|.:||.    |...|..::.||:|.||.|.|||:.| ||  .
Worm    10 LWWHSHLTISTRHISPFELRVNSGAIRGERLLTDGQDYSVFKGIPFAMPPVGYLRFQMPKEP--A 72

  Fly    72 KWSDIFDATKTPVACLQ-WDQFTPG-ANKLVG--EEDCLTVSVYKPK--NSKRNSFPVVAHIHGG 130
            ||..:.:||:....|:| .|:...| ..:.|.  .||||.::|:.|.  ....:::||:..||||
Worm    73 KWRGVMNATQYSAMCMQNIDENDAGEPERYVAHVSEDCLYLNVFSPTPYQYTNDTYPVIVFIHGG 137

  Fly   131 AFMFGAAWQNGHENVMR---EGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQN 192
            .|..|:........::.   ..|.:.|..:||||||||.||||..||||.||.||..||||:|.|
Worm   138 RFQTGSGSDIPQRAILSNFVSRKIVFVTFNYRLGPLGFASTGDSVLPGNIGLWDQIWALKWVKAN 202

  Fly   193 IASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGR 257
            ...|||:|.|:||:||..|.||..|..|......|.:.....||:||.|.|::.......:.:..
Worm   203 AEVFGGDPSNILLMGHGTGAASASLLALSPRAEGLFQKVLLMSGSALQPGVVRNTQVNATWNMND 267

  Fly   258 NVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYV-----PFAPFSPVLEPSDAPDAIITQD 317
            ..||. |.:|:.|..|.:.:...|         ||.|.     .:..|.|::   |....|:.:.
Worm   268 RFGCR-AFNSSELLDCARKRSKEE---------IFQYKRLHFDDYEEFVPII---DGVGGILPEP 319

  Fly   318 PRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLN------ERWLELAPYLLFYR 376
            |..:....:  :.|..:. .|:|......|||.|:       |||      |....||..|
Worm   320 PEQLTLHRR--KTPIVIG-TTKDESSLRILLLNEK-------DLNFSSITWENGETLADNL---- 370

  Fly   377 DTKTKKDMDDY---SRKIKQEYIGNQ---RFDIES--YSELQRLFTDILFKNSTQESLDLHRKYG 433
             |...|...::   |:..|.||:..|   .|. ||  ::.|.::::...:.....:....:.|:
Worm   371 -TLGFKQFQNHRLISQGCKSEYVWTQVDPSFP-ESVLFNSLLKMYSHFWYDAPASQLATYYLKH- 432

  Fly   434 KSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFE------NFVRDVEMRPDEQIISR 492
            ..|.|.|.:|:.:|        |..|.| ...||.|...||.      |..:|:..:.|:::: .
Worm   433 DLPVYLYSFDHISE--------NFYDID-RAFHGVDKLHIFNVTPRFLNKRKDMNWQLDQRVV-E 487

  Fly   493 NFINMLADFA 502
            .|..::|:||
Worm   488 IFSELVANFA 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	150/513 (29%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	58/137 (42%)
cest-19	NP_509187.4	Abhydrolase	27..544	CDD:389770	150/513 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_109642
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810