DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and glit-1

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_508807.1	Gene:	glit-1 / 180747	WormBaseID:	WBGene00018878	Length:	730	Species:	Caenorhabditis elegans

Alignment Length:	599	Identity:	148/599 - (24%)
Similarity:	247/599 - (41%)	Gaps:	162/599 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GSNASDTDDPLLVQLPQGKLRGRD----------------------------------NGSYYSY 48
            |.|.....|.::|:||.|.:.|::                                  |.:.:::
Worm    45 GVNQGLNRDEVVVRLPLGDIVGKEVHLHNLPWTIHKDPTEELPKDGTHFDPNPLKPKNNITVFTF 109

  Fly    49 ESIPYAEPPTGDLRFEAPE-----PYKQKW-------SDIFDATKTPVACLQWDQFTPGANKLVG 101
            ..:|||||||...||:.|:     |.||.:       |...|..|:|      ..|.......:.
Worm   110 LGVPYAEPPTSQRRFKPPQQLTVFPGKQPYLAFNYAASCAQDVEKSP------SPFVDHPYPFMV 168

  Fly   102 EEDCLTVSVYKPKNSK--RNSFPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLG 164
            :||||.::::.|..||  :.::||:...|||.|..|:|.:.....:...| .::|.::||||..|
Worm   169 DEDCLYLNIFSPDISKNAQTTYPVIVFFHGGNFQTGSANEWPAHGLASRG-MVVVTVNYRLGAFG 232

  Fly   165 FVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLAR 229
            |:|.||.: .|||||:||||||:::|.||.:|||:||.|.:|||.||.||:...|.......|.|
Worm   233 FMSMGDSE-TGNYGLQDQRLALEFVKNNIVTFGGDPQAVTVVGHDAGAASIGFHMQSPYSRHLFR 296

  Fly   230 AAFSFSGNALDPWVIQKGARGRAF----ELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFL 290
            :|.:.||..:. :....|....||    :|||..||..|. :.....|:.::...:::.|.|...
Worm   297 SAATMSGAEVS-YHSYIGKTALAFNNTMKLGRYAGCTQAV-AQHRWDCILTRSTGDIIDATRNIP 359

  Fly   291 I----FSYVP-----FAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAA 346
            |    :.::|     :.|.:|:....:||..          ::.....||..:....:||   :.
Worm   360 IEYNRYLFMPTVDGKYLPGNPLWTLVNAPSG----------ETSIMSPVPMLIGMNAQDG---SE 411

  Fly   347 LLLKERKSG--IVIDDLNERWLELAPYLLFY---------RDTKTKKDMDDY--------SRKIK 392
            ::|::|:.|  ...:|::..:|:  .|.|.|         |:......:..|        :..||
Worm   412 VVLEDRRLGEFSQFNDVDHEYLK--SYSLEYCYRHNYSMNREATADAILSKYTFWPDRAAAWAIK 474

  Fly   393 QEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANR 457
            :.:|              :..||..:....|.|..||...| |..:.||
Worm   475 ENFI--------------QFATDAYYTAPMQLSSHLHSSSG-SRVFQYV---------------- 508

  Fly   458 TDYDFGTVHGD--------------DYFLIF-ENFVRDVEMRP----------DEQIISRNFINM 497
            .:|:|...|.:              |.:|:| ..|:.| |:||          .::..||.|.|:
Worm   509 NNYNFSRQHPNLLFIPDWMGVCRDCDLYLMFGYPFLPD-ELRPIGLRGINFTDTDRNASRTFSNI 572

  Fly   498 LADFASSDNGSLKY 511
            :..|:...|.:.::
Worm   573 IRRFSYHQNPNFQF 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	145/588 (25%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	55/134 (41%)
glit-1	NP_508807.1	COesterase	56..629	CDD:365897	145/588 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810