DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and cest-2.3

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_506510.2	Gene:	cest-2.3 / 179918	WormBaseID:	WBGene00013873	Length:	665	Species:	Caenorhabditis elegans

Alignment Length:	541	Identity:	127/541 - (23%)
Similarity:	213/541 - (39%)	Gaps:	133/541 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VQLPQGKLRGRDNGSYYS---------YESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVA 85
            :||..|.:.|:...:.||         :..|||.|||.|:|||..|...| .|..:.:......|
Worm    20 IQLSTGTIEGKILNATYSPFGNQTATVFLGIPYVEPPIGELRFRKPRLLK-SWEGVLETKDYKPA 83

  Fly    86 CLQWDQFTPGANKLVGE--EDCLTVSVYKPKNSKRN-SFPVVAHIHGGAFM--FGAAWQNG---H 142
            |:.:.:.| ..|..|||  ||||..:|:..:...:| :..|:..:|||..:  .|:|::..   :
Worm    84 CMSYWRKT-FKNGFVGEISEDCLYANVFTNQYCLQNKNCSVMIVVHGGRLVCESGSAFKPEIFIN 147

  Fly   143 ENVMREGKFILVKISYRLGPLGF----VSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNV 203
            ..|.::...::|..:||||..||    ..|||.    |..:.|...|:||:::.|..|||....:
Worm   148 NFVGQDRNIVVVTFNYRLGVFGFGVFNGETGDT----NVAMYDMLEAVKWVRKEIDQFGGNKDRI 208

  Fly   204 LLVGHSAGGASV-------------HLQMLR----EDFGQLARAAFSFSGNALDPWVIQKGARGR 251
            .:.|||||...:             |.|::.    :|..:.|    :|.|..:
Worm   209 TMAGHSAGAGLIVDFTSSTLSKGLLHQQIVMSAPLQDISKSA----NFKGMTI------------ 257

  Fly   252 AFELGRNVGCESAE------DSTSLKK---CLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEP- 306
               :.:||||...|      ..|.:.|   ||::|.|.:|:.|.......|...|.  ||.::.
Worm   258 ---VAQNVGCIPKEYGFRKLSKTQINKTYLCLQNKSAQDLLHAQLSMQQNSTFYFG--SPRVDGD 317

  Fly   307 --SDAPDAIITQDPRDVIKSGKFGQV-PWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLEL 368
              :|.||.:.           .|..: |......|..|....:|.:.:.|:..:.:.|.:...|.
Worm   318 FITDYPDNLF-----------NFNTIYPINTFIGTTTGELRDSLYITDPKNDRIKEQLLKNMCEH 371

  Fly   369 APYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHRKYG 433
            ..|.||.:.       :::::|....|        ::.::.|.|..|:.|.:...:..:.|:: .
Worm   372 VGYELFEKP-------EEFTKKCGNYY--------KNGTDAQFLSDDMEFYSGAIKVANAHKR-A 420

  Fly   434 KSPAYAYVYDNPAEKGIAQVLANRTD-----------YDFGTVHGDDYFLIFENFVRDVEMRPDE 487
            .|..:.|.||   .||.........:           |.|||..|.        ||      ..:
Worm   421 NSKVFMYSYD---YKGAGTAFHKYLEAPSPHHSEDLIYTFGTSRGP--------FV------AKD 468

  Fly   488 QIISRNFINMLADFASSDNGS 508
            .:|.|.:..|||:|.:.::.|
Worm   469 YVIERIYSGMLANFINFEDPS 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	127/541 (23%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	39/159 (25%)
cest-2.3	NP_506510.2	Abhydrolase	20..532	CDD:389770	127/541 (23%)
cest-2.3	NP_506510.2	CemA	<550..>647	CDD:383495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156996
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840