DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and cest-2.1

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_506508.2	Gene:	cest-2.1 / 179916	WormBaseID:	WBGene00013875	Length:	675	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	143/560 - (25%)
Similarity:	224/560 - (40%)	Gaps:	131/560 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IVLSCLWLGSNASDTDDPLLVQLPQGKLRGRDNGSYYS---------YESIPYAEPPTGDLRFEA 65
            :||..|:|.|..........|||..|.:.|:...|.||         :..||:.|||.|:|||..
Worm     1 MVLLFLFLLSTLLHISISTRVQLSTGTIEGKILTSTYSPLGNHTGIGFLGIPFVEPPAGNLRFRK 65

  Fly    66 PEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVG--EEDCLTVSVYKPKN-SKRNSFPVVAHI 127
            |.| ...|..|.:..:...||:. |......|.:.|  .||||..:|:..:. .||.:..|:..:
Worm    66 PRP-PIPWDGILETKEYKPACMS-DAKKTYKNGVGGPISEDCLYANVFTNQYCMKRKNCSVMIVV 128

  Fly   128 HGGAFMFGAAWQNGHE----NVMREGK-FILVKISYRLGPLGF-VSTGDRDLPGNYGLKDQRLAL 186
            |||..:..:|.....|    |.:.:|: .::|..:||||..|| |..|::. ..|.|:.|...|:
Worm   129 HGGRILTESASAFNPEILVNNFVGQGRNIVVVTFNYRLGTFGFGVLNGEKG-DSNVGMFDMLEAV 192

  Fly   187 KWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFS---FSGNALDPWVIQKGA 248
            ||.::.:.:|||....:.:|||||||:.|              .||:   .|...|:..:|..||
Worm   193 KWTRKEVHNFGGNKDKLTMVGHSAGGSLV--------------GAFTSSPLSKGMLNQQIIMSGA 243

  Fly   249 RGRAFELGR------------NVGC-----------ESAEDSTSLKKCLKSKPASELVTA----V 286
               .:::|:            ..||           :...|.|  ..||::..|.|::.|    :
Worm   244 ---LYQMGKLANFKGMTAMAQKAGCLPEVFGFRKLSQVRIDKT--YSCLRNISAQEVLDAQLWVL 303

  Fly   287 RKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKE 351
            :....:..||......:|..||           :::.||....:...:...|           .|
Worm   304 QNTTYYISVPHIDGEFLLNYSD-----------EILASGTIHPINSMIGTTT-----------AE 346

  Fly   352 RKSGIVIDDLN--ERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFT 414
            .:..|.|:||.  ::..||...|..:...:...:.:::|||. |::.||.       .:.|.|..
Worm   347 LRDPIYINDLKNADKKEELLKNLCEHIGYELYTEPEEFSRKC-QKFYGNG-------DDAQFLAD 403

  Fly   415 DILFKNSTQESLDLH-RKYGKSPAYAYVYDN--PAEKGIAQV----LANRTDYDFGTVHGD---- 468
            |:.|.:.:.:..:.| .|..|...|:|.|.:  ||.|..||.    .:....|.|||..|:
Worm   404 DMEFYDGSIKVANAHASKNTKVFMYSYDYKDAGPAFKKYAQAPPPHHSEDLIYVFGTSRGNFTEK 468

  Fly   469 DYFLIFENFVRDVEMRPDEQIISRNFINMLADFASSDNGS 508
            ||.:              |||.|    .|.|||.:..|.|
Worm   469 DYVI--------------EQIYS----GMFADFVNFGNPS 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	138/541 (26%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	41/142 (29%)
cest-2.1	NP_506508.2	COesterase	21..533	CDD:365897	138/540 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157000
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840