DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and cest-1.1

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_506506.1	Gene:	cest-1.1 / 179915	WormBaseID:	WBGene00011362	Length:	673	Species:	Caenorhabditis elegans

Alignment Length:	549	Identity:	127/549 - (23%)
Similarity:	218/549 - (39%)	Gaps:	135/549 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VQLPQGKLRGR---------DNGSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVA 85
            |||..|.:.|:         .|.|...:..||:.|||.||||:..|.|.| .|..:....:...|
Worm    19 VQLSSGTIEGKILNISYSPLGNQSATVFLGIPFVEPPIGDLRYRKPRPPK-SWEGVLVTNEYKSA 82

  Fly    86 CLQWDQFTPGANKLVG--EEDCLTVSVYKPKNSKRN-SFPVVAHIHGGAFMFGAAWQNGHE---- 143
            |:. :......||..|  .||||.::|...:....| :..|:..:|||.::..:|.....|
Worm    83 CMS-NATKTYKNKFGGPISEDCLYLNVLTNEYCLENKNCSVMMIVHGGGYLTESASTFNPEILIN 146

  Fly   144 NVMREGK-FILVKISYRLGPLGFVS-TGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLV 206
            |.:.:|: .::|..:||||...|.. .|||. ..|:||.|...::.|:::.|.:|||....:.|.
Worm   147 NFVGQGRNIVVVTFNYRLGLFSFGQFNGDRG-DKNFGLYDMIESVNWVRREIENFGGNKNRITLA 210

  Fly   207 GHSAGGAS-------------VHLQMLRE-DFGQLARAAFSFSGNALDPWVIQKGARGRAFELGR 257
            |||||.:.             ||.|::.. ....:::.: :|.|..:               :.:
Worm   211 GHSAGASMIVAFTSSPLTKGLVHQQIIMSAPMTNMSKKS-NFKGMTV---------------MAQ 259

  Fly   258 NVGC------------ESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAP 310
            .|||            |..|::.|   ||:.|.|.:::.| :.:|:.:...|....|:      .
Worm   260 MVGCLSEEIGFNKLSEEQVENTYS---CLRKKSAQQILDA-QLWLLQNSTYFLGAPPI------D 314

  Fly   311 DAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVID--------DLNERWLE 367
            :..:|..|.::..|.....:...:...|          |:..:|..:||        :|.|...:
Worm   315 EHFLTDYPENLYASKSIYPINTLIGTTT----------LEVEESSYIIDPAFADKKVELLENLCD 369

  Fly   368 LAPYLLFYRDTKTKKDMDDYSRKIKQEYI-GNQRFDIESYSELQRLFTDILFKNSTQESLDLHRK 431
            ...|:|:       ::.:.:|:|.:::|: ||...::.:..|         |.....:..|.|..
Worm   370 HIGYVLY-------EEPETFSKKCQKQYMNGNSSMNLSNEME---------FYTPAIDFADSHTS 418

  Fly   432 YGKSPAYAYVYD----NPAEKGIAQVLANRTD----YDFGTVHGDDYFLIFENFVRDVEMRPDEQ 488
             |.:..:.|.||    .||.....:|.:....    |.|||..|     ||         .|.:.
Worm   419 -GNTKVFLYSYDYRGAGPAYDRYLEVRSPHHSEDLIYVFGTHRG-----IF---------APKDY 468

  Fly   489 IISRNFINMLADFASSDN----GSLKYGE 513
            ||.:.:..|.|||.:.:|    |..|:.:
Worm   469 IIEKIYSGMFADFVNFENPLPSGDQKWNQ 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	127/549 (23%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	39/153 (25%)
cest-1.1	NP_506506.1	COesterase	19..531	CDD:278561	127/549 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157002
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840