DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and cest-1.2

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_506504.2	Gene:	cest-1.2 / 179914	WormBaseID:	WBGene00011364	Length:	676	Species:	Caenorhabditis elegans

Alignment Length:	577	Identity:	151/577 - (26%)
Similarity:	227/577 - (39%)	Gaps:	129/577 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IVLSCLWLGSN-ASDTDDPLLVQLPQGKLRGRDNGSYYS---------YESIPYAEPPTGDLRFE 64
            :||  ||..:. |..|.    |||..|.:.|:...|.||         :..|||.|||.|||||.
Worm     6 VVL--LWFSAQFAISTK----VQLSTGIIEGKQLNSTYSPFGNQSAIAFLGIPYVEPPIGDLRFR 64

  Fly    65 APEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVG--EEDCLTVSVYKPKNSKRN-SFPVVAH 126
            .|.|.| .||.:.:..|...||:.....|.....:.|  .||||.::|...:....| :..||..
Worm    65 KPRPQK-TWSGVLETKKFKPACMSNSTKTYKNGGIGGPISEDCLYLNVLTNQYCLENKNCSVVII 128

  Fly   127 IHGGAFMFGAAWQNGHENVM-----REGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLAL 186
            :|||.::|.:|....||.::     ::...::|.|:||||..||......:...|.|:.|...|:
Worm   129 VHGGGYLFESAATFNHEILVNNFVGQDRNIVVVTINYRLGIFGFGHLNGFEGDKNVGIFDTLEAV 193

  Fly   187 KWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFS---GNALDPWVIQKG- 247
            ||:::.|..|||....:.|.|||||...|              |||:.|   ...:...::..|
Worm   194 KWVRREIKQFGGNKDRITLAGHSAGAGVV--------------AAFTISPLTKGLIHQQIVMSGP 244

  Fly   248 ----ARGRAFE----LGRNVGCESAE---------DSTSLKKCLKSKPASELVTAVRKFLIFSYV 295
                ::...|:    :...|||.|.:         :...:..||:.|||.||:.|....|..|..
Worm   245 MTNMSKKSNFKGMTAMAERVGCHSKKYGFNKLPEHEVEQVYSCLRKKPAQELLDAQLWLLQNSTF 309

  Fly   296 PF-APFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVT---EDGGY--NAALLLKERKS 354
            .| ||      |.|.  ..||..|.::........:...:...|   :|.||  |:.....|.|.
Worm   310 YFGAP------PVDG--EFITDYPDNLYSEKSIFSINTLLGTTTRELQDTGYISNSNYSKFETKE 366

  Fly   355 GIVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFK 419
            ..:.:..::..:|:            .|:.:|:|.|.::.||..        |:.:.|..|:.|.
Worm   367 TFLKNLCDQIGIEI------------YKESEDFSSKCQKWYING--------SDSKSLSDDMEFY 411

  Fly   420 NSTQESLDLHRKYGKSP---AYAYVYDNPAEKGIAQVLANRTD----YDFGTVHGDDYFLIFENF 477
            .......|.|.:.||..   :|||....||.|...:|.:....    |.|||..|     :|
Worm   412 TQAINLADAHARKGKKVYMYSYAYSGAGPAFKKYMKVKSPHHSEDLIYTFGTHRG-----VF--- 468

  Fly   478 VRDVEMRPDEQIISRNFINMLADF-------ASSDNGSLKYGE-------CDFKDNV 520
                  .|.:.:|...:..|.|||       .|:|...|:|.:       .||..|:
Worm   469 ------APKDYVIEYIYSGMFADFINFEDPSPSTDQPWLQYTKENKEYFLVDFDQNL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	145/557 (26%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	40/141 (28%)
cest-1.2	NP_506504.2	COesterase	21..536	CDD:278561	145/556 (26%)
cest-1.2	NP_506504.2	Aes	<125..>250	CDD:223730	39/138 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156998
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840