DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and cest-33

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_504621.1	Gene:	cest-33 / 179020	WormBaseID:	WBGene00017431	Length:	554	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	149/568 - (26%)
Similarity:	239/568 - (42%)	Gaps:	121/568 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GKLRG----RDNGSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQWDQFTPG 95
            |.:||    .|:.....|..||||:||.|:|||:.|... ..|::|.|..|...||:|    |.|
Worm    22 GPVRGNIYKHDDVIVDGYLGIPYAKPPVGELRFKKPVTV-DVWTEIKDCYKYGPACVQ----TGG 81

  Fly    96 ANKLVG-------EEDCLTVSVYKPKNSK---RNSFPVVAHIHGGAFMFGA-----AWQNGHENV 145
            ..::.|       |..|||::|:.|:|:.   :|..||:.:||||.:...|     |:.......
Worm    82 FEQIAGPRTPTPEEAGCLTLNVFTPRNASSEFKNGRPVMVYIHGGGYELCASSDFCAYSLSGTLP 146

  Fly   146 MREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSA 210
            :::  .::|.|:||||..||::|||...|||:||.||.|||||::::|:||||:|..|.:.|.||
Worm   147 LKD--VVVVSINYRLGVFGFLTTGDNVCPGNFGLWDQTLALKWVQKHISSFGGDPNCVTVFGQSA 209

  Fly   211 GGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVGCESAE-------DST 268
            ||||..|..|......|.:.....||.|...:.|      ||.|....:..|.||       ||:
Worm   210 GGASTDLLSLSPHSRDLFQRFIPISGTAHCDFAI------RASENQAKIFREFAEFHGFSGRDSS 268

  Fly   269 SLKKCLKSKPASEL--VTAVRKFLIFSYVPFAPFSPVLEPSDAP---DAIITQDPRDVIKSGKFG 328
            :|.|..:.:....|  |...:|    |...|..|.|.|:....|   |.:..:.|:..:.:|
Worm   269 ALFKWYQEQSPETLSNVKGYKK----SISGFLTFIPNLDGDFFPKPLDELRKEAPKKQMMTG--- 326

  Fly   329 QVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERW------LELAPYLLFYRDTKTKKDMDDY 387
                    |||             ..|:::..:|..:      |.|.|..::.:|..:  :.|:.
Worm   327 --------VTE-------------YEGLMLASMNPAFSPADVGLTLMPQGIYGKDVVS--NPDEI 368

  Fly   388 SRKIKQEYI-GNQRFD-IESYSELQRLFTDILFKNSTQESLDLHRKYGKSP-AYAYVYDNPAEKG 449
            .:...::|: |..:.| :....:|.....|..|.....::.....|:|... .|.:.|.||...|
Worm   369 QKIFYEKYVEGVDKSDELAMRKKLCEALGDEFFNVGVIQAAKNAAKHGNEVYFYTFEYVNPDSFG 433

  Fly   450 IAQVLANRTDYD-----FGTVHGDDY-FLIFENFVRDVEMRPDEQIISRNFINMLADFA--SSDN 506
            :         :|     ...||..:. :|:.|......|...:::.:......:.::||  .:.|
Worm   434 M---------WDGMMPFKAAVHCTELRYLLGEGVYSKFEPTEEDRKVMETTTTLFSNFAKYGNPN 489

  Fly   507 GS--------------------LKYGECDFKDNVGSEKFQLLAIYIDG 534
            |.                    :.|.:|:.:|.....:.|.|. .|||
Worm   490 GKGATAEIWEKYSLNRPERHYRISYPKCEMRDVYHEGRIQFLE-KIDG 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	149/568 (26%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	55/140 (39%)
cest-33	NP_504621.1	Esterase_lipase	16..521	CDD:238191	143/550 (26%)
cest-33	NP_504621.1	Aes	<103..>224	CDD:223730	51/122 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810