DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and cest-4

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_501043.1	Gene:	cest-4 / 177445	WormBaseID:	WBGene00015930	Length:	592	Species:	Caenorhabditis elegans

Alignment Length:	564	Identity:	128/564 - (22%)
Similarity:	218/564 - (38%)	Gaps:	128/564 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGRDNGSYYSYESIPYAEPPTGDLRFEAPEPYKQK 72
            |::.||...|.|.....    :|....|::.|...||::.::.||.|:||.|.|||:.||| .:|
Worm    11 LLLFLSFFLLFSITKSA----IVSTSLGQIDGDQIGSFHLFKHIPLAKPPIGKLRFQKPEP-PEK 70

  Fly    73 WSDIFDATKTPVACLQWDQFTPGANKLVGEEDCLTVSVY-KPKNSKRNSFPVVAHIHGGAFMFGA 136
            |:.:.:|.....||:.....:....|.: :||||.:::: ..|..|.....||.:.|||..|:.:
Worm    71 WTGVRNAKAYGPACISNSSVSTSPQKWI-DEDCLHINIFTSDKCLKSKDCAVVTYFHGGGLMYDS 134

  Fly   137 AWQNGHENVMREGKF----ILVKI-SYRLGPLGFVSTGDRDL-PGNYGLKDQRLALKWIKQNIAS 195
            |.......::  |.|    :::.| ::|||........|:.: |.|..|.|..|.::::|..|.:
Worm   135 AVMFNDTYLL--GTFVNQDVIIAIPAFRLGIFSHFVVEDQSIAPTNLALYDILLGVEFVKNEIHN 197

  Fly   196 FGGEPQNVLLVGHSAGGASVHL----QMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELG 256
            |||..|...::|||.||:.|::    ..:..|.....::....||:..:...||.....|   ..
Worm   198 FGGNNQKNTIMGHSYGGSIVNILTFSSKINHDLSLFQQSICMSSGHDFETLEIQIQKTNR---FA 259

  Fly   257 RNVGC----------ESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAP- 310
            ::.||          .:.:......|||::|.|.||:...|               :||....|
Worm   260 KHAGCTVPSIIEKKMTTRQSDLYRMKCLQNKDALELLRVQR---------------LLEDEGYPT 309

  Fly   311 -------DAIITQDP-RDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLE 367
                   :.:|.:.| ::.:||.|  ::|........:..::.|  .|.....:..::..|.::
Worm   310 YGYLVQREPLIQEIPYQEFMKSPK--KIPMLTGCTRYEMDHSPA--PKPIGQALGFENPEEVYM- 369

  Fly   368 LAPYLLFYRDTKTKKDMDDYSRKIKQEY-IGNQRFDIESYSELQRL-FTDILFKNSTQESLDLHR 430
                       |.:||.||      :.| .||...:.::.....|: ..::|.||
Worm   370 -----------KFRKDWDD------EVYEFGNHSDETQAIMVQVRVRVNNLLSKN---------- 407

  Fly   431 KYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLI-----FENFVRDVEMRPDEQII 490
                .|||.|.|..|..                ..|.||.|.:     ||....::|:....:.|
Worm   408 ----VPAYLYEYTYPKH----------------ARHTDDLFYLMGVHRFEKDENEIELGKVYETI 452

  Fly   491 SRNFINMLADFASSDNGSLKYGECDFKDNVGSEKFQLLAIYIDG 534
            ..||    |.|.....|.         :...:|......:|.||
Worm   453 FMNF----AKFGDPKEGF---------ELANAENESYYEVYWDG 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	123/543 (23%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	36/143 (25%)
cest-4	NP_501043.1	Abhydrolase	28..503	CDD:389770	123/543 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810