DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and cest-5.1

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_501022.3	Gene:	cest-5.1 / 177429	WormBaseID:	WBGene00015279	Length:	580	Species:	Caenorhabditis elegans

Alignment Length:	586	Identity:	137/586 - (23%)
Similarity:	214/586 - (36%)	Gaps:	173/586 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNYVGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGRDNGSYYSYESIPYAEPPTGDLRFEA 65
            ||.:.|.|:|.:      .||:|:   |::....|.|.|.:.|.|:.::.||:|:||.|:|||:.
Worm     1 MNTLRLLLLIFI------INAADS---LIIHTSFGHLEGAEIGDYHLFKKIPFAKPPVGNLRFQK 56

  Fly    66 PEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVGEEDCLTVSVYKPKNS-KRNSFPVVAHIHG 129
            ||. ..||..|..|.:...||:.....|....|.| :||||.|:::..|.. |..:..:..:|||
Worm    57 PEA-AGKWDGIRSAIEYGPACMSNSSKTKSPQKWV-DEDCLHVNIFTSKKCLKSRNCAIAVYIHG 119

  Fly   130 GAFMFGAAWQNGHENVMRE----GKFILVKISYRLGPLGFVSTGDRDL-PGNYGLKDQRLALKWI 189
            |...:.:|.. .::.|:.:    ...|||...:|||.....:..:::: |.|..|.|..|||:::
Worm   120 GGLTYDSAVM-FNDTVLLDTFVKRDVILVIPGFRLGIFSHFTVHNQNVAPNNLALYDITLALEFV 183

  Fly   190 KQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQ---LARAAFSFSGNALDPWVIQKGARGR 251
            |..|.||||..|.:.|.|||.||....:.....:..:   |.:.|...||             |.
Worm   184 KSEIHSFGGNSQKITLFGHSYGGGLASMMTFSSEINRDLSLFQQAIVMSG-------------GF 235

  Fly   252 AFE-----------------------LGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFS 293
            .||                       |.|.:  |.::....:.|||:.....||:...|
Worm   236 YFEELKDHIEGTKRFVEYANCSVPLKLERKM--ERSQQEMYMMKCLQKLSGMELLRIQR------ 292

  Fly   294 YVPFAPFSPVLEPSDAPD--AIITQDPR-------DVIKSGKFGQVPWAVSYVTEDGGYNAALLL 349
                     :||....||  .:|.::|.       :::||.|  .:|........:..:.:   :
Worm   293 ---------LLEDKGYPDFGGVILREPLFPDVKKFELLKSPK--NIPMLTGCTNLEFDHES---I 343

  Fly   350 KERKSGIVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFT 414
            |               :....||.|       ::.|:...|        .|.|:||..|.:...|
Worm   344 K---------------VPFGKYLEF-------ENPDECDEK--------YRNDVESGVENRGNHT 378

  Fly   415 D---------------ILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTD---YD 461
            |               :|..|.|              ||.|.|..|..       ...||   |.
Worm   379 DKTQGIILPLKLQINNLLENNVT--------------AYLYEYTYPKH-------GRHTDDLSYI 422

  Fly   462 FGTVHGDDYFLIFENFVRDVEMRPDEQIISRNFINML------ADFASSDNGSLKYGECDFKDNV 520
            .| ||.      ||....:|.:   ||:.....||.:      ..|..|:.....|.:..:.:..
Worm   423 MG-VHA------FEKDENEVHL---EQVYKDMVINFIKLGEPGMGFEKSEQNESTYFDIYWNETT 477

  Fly   521 G 521
            |
Worm   478 G 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	128/558 (23%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	38/141 (27%)
cest-5.1	NP_501022.3	Abhydrolase	19..495	CDD:389770	129/559 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156870
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740