Protein Alignment Est-6 and cest-5.1

DIOPT Version :10

• Sequence 1: NP_788500.1
• Gene: Est-6 / 39392
• FlyBaseID: FBgn0000592
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_501022.3
• Gene: cest-5.1 / 177429
• WormBaseID: WBGene00015279
• Length: 580
• Species: Caenorhabditis elegans
• Alignment Length: 586
• Identity: 137/586 - (23%)
• Similarity: 214/586 - (36%)
• Gaps: 173/586 - (29%)

  Fly     1 MNYVGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGRDNGSYYSYESIPYAEPPTGDLRFEA 65
            ||.:.|.|:|.:      .||:|:   |::....|.|.|.:.|.|:.::.||:|:||.|:|||:.
 Worm     1 MNTLRLLLLIFI------INAADS---LIIHTSFGHLEGAEIGDYHLFKKIPFAKPPVGNLRFQK 56

  Fly    66 PEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVGEEDCLTVSVYKPKNS-KRNSFPVVAHIHG 129
            ||. ..||..|..|.:...||:.....|....|.| :||||.|:::..|.. |..:..:..:|||
 Worm    57 PEA-AGKWDGIRSAIEYGPACMSNSSKTKSPQKWV-DEDCLHVNIFTSKKCLKSRNCAIAVYIHG 119

  Fly   130 GAFMFGAAWQNGHENVMRE----GKFILVKISYRLGPLGFVSTGDRDL-PGNYGLKDQRLALKWI 189
            |...:.:|.. .::.|:.:    ...|||...:|||.....:..:::: |.|..|.|..|||:::
 Worm   120 GGLTYDSAVM-FNDTVLLDTFVKRDVILVIPGFRLGIFSHFTVHNQNVAPNNLALYDITLALEFV 183

  Fly   190 KQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQ---LARAAFSFSGNALDPWVIQKGARGR 251
            |..|.||||..|.:.|.|||.||....:.....:..:   |.:.|...||             |.
 Worm   184 KSEIHSFGGNSQKITLFGHSYGGGLASMMTFSSEINRDLSLFQQAIVMSG-------------GF 235

  Fly   252 AFE-----------------------LGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFS 293
            .||                       |.|.:  |.::....:.|||:.....||:...|
 Worm   236 YFEELKDHIEGTKRFVEYANCSVPLKLERKM--ERSQQEMYMMKCLQKLSGMELLRIQR------ 292

  Fly   294 YVPFAPFSPVLEPSDAPD--AIITQDPR-------DVIKSGKFGQVPWAVSYVTEDGGYNAALLL 349
                     :||....||  .:|.::|.       :::||.|  .:|........:..:.:   :
 Worm   293 ---------LLEDKGYPDFGGVILREPLFPDVKKFELLKSPK--NIPMLTGCTNLEFDHES---I 343

  Fly   350 KERKSGIVIDDLNERWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFT 414
            |               :....||.|       ::.|:...|        .|.|:||..|.:...|
 Worm   344 K---------------VPFGKYLEF-------ENPDECDEK--------YRNDVESGVENRGNHT 378

  Fly   415 D---------------ILFKNSTQESLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTD---YD 461
            |               :|..|.|              ||.|.|..|..       ...||   |.
 Worm   379 DKTQGIILPLKLQINNLLENNVT--------------AYLYEYTYPKH-------GRHTDDLSYI 422

  Fly   462 FGTVHGDDYFLIFENFVRDVEMRPDEQIISRNFINML------ADFASSDNGSLKYGECDFKDNV 520
            .| ||.      ||....:|.:   ||:.....||.:      ..|..|:.....|.:..:.:..
 Worm   423 MG-VHA------FEKDENEVHL---EQVYKDMVINFIKLGEPGMGFEKSEQNESTYFDIYWNETT 477

  Fly   521 G 521
            |
 Worm   478 G 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_788500.1	Esterase_lipase	29..537	CDD:238191	128/558 (23%)
cest-5.1	NP_501022.3	alpha/beta hydrolases	17..495	CDD:473884	130/564 (23%)