DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and ace-4

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_496962.1	Gene:	ace-4 / 175074	WormBaseID:	WBGene00000038	Length:	602	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	141/551 - (25%)
Similarity:	228/551 - (41%)	Gaps:	125/551 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PLLVQLPQGKLRGRD----NGSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACL 87
            |::::...|.::|.:    :....::..:|:|||...|.||..|...|| |..::||||...||.
Worm    26 PVVLETKLGDIKGTEFFFLSKKIRTFFGVPFAEPAVEDFRFRKPREKKQ-WRGLYDATKPANACF 89

  Fly    88 Q---------WDQFTPGANKLVGEEDCLTVSVYKPKNSKRNSFPVVAHIHGGAFMFGAAWQNGHE 143
            |         |......||..: .||||.::::.|.::  .:..|:....||.|..|:...:
Worm    90 QTRDNYNTSFWGSEMWNANTQI-SEDCLYLNIWAPADA--YNLTVMVWFFGGGFYSGSPSLS--- 148

  Fly   144 NVMREGK-------FILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQ 201
              :.:||       .|:|.|:|||||.||:..|..|.|||.||.||:|||.|::|||.||||.|.
Worm   149 --IYDGKALTSTQNVIVVNINYRLGPFGFLYLGHPDAPGNMGLLDQQLALHWVRQNIVSFGGNPD 211

  Fly   202 NVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQK--GARGRAFELGRNVGCESA 264
            .|.:.|.|||.||:...::......|.:.|...||:..:.|.|..  .|:.::.:|...|||...
Worm   212 KVAVFGQSAGAASIVAHLIAPGSRGLFKNAILQSGSLENTWAINSPFRAKQKSEKLLELVGCNKT 276

  Fly   265 EDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQ--------DPRDV 321
            ...||: .||:.....:|..:... :..:|:.|            |..|:::        |....
Worm   277 TVDTSM-ACLRLVSPEQLSLSTWN-ISLTYLEF------------PFVIVSRDKHFFGHLDAHAA 327

  Fly   322 IKSGKFGQ-VPWAVSYVTEDGGYNAALLLKE--------RKSGIVIDDLNERWLELAPYLL---- 373
            ::.|.|.: |...:....::|.|.....|.:        ..:....|.|.:|...:.|.::
Worm   328 LREGDFNRDVNLMIGMNKDEGNYWNIYQLPQFFDKADPPELNRTEFDFLIDRTFSIQPDIIRSAA 392

  Fly   374 --FYRDTKTKKDMDDYSRKIK------QEYIGNQRFDIES------YSELQRLFTDILFKNSTQE 424
              .|.|    .:..|:.||.:      .:.:|:..|..:|      :..:.|:      |:|:.:
Worm   393 KYIYSD----PNCTDHGRKTRFYAGQMNQIVGDYFFSCDSLWLADQFRSIPRV------KSSSPQ 447

  Fly   425 SLDLHRKYGKSPAYAYVYD---NPAEKGIAQVLANRTDYDFGTVHGDDYFLIF-------ENFVR 479
                 ||.||...|.:...   ||..|..            |.:||.:...:|       :|:.|
Worm   448 -----RKPGKVFVYHFTQSSSANPWPKWT------------GAMHGYEIEYVFGIPLSYSKNYKR 495

  Fly   480 DVEMRPDEQIISRNFINMLADFASSDNGSLK 510
                  .|||.||..:...|.||.  ||:.|
Worm   496 ------REQIFSRKIMQFWASFAK--NGTPK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	140/549 (26%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	50/139 (36%)
ace-4	NP_496962.1	COesterase	28..562	CDD:278561	140/549 (26%)
ace-4	NP_496962.1	Aes	<120..>243	CDD:223730	48/129 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156954
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840