DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and ace-2

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_491141.1	Gene:	ace-2 / 171905	WormBaseID:	WBGene00000036	Length:	629	Species:	Caenorhabditis elegans

Alignment Length:	529	Identity:	138/529 - (26%)
Similarity:	222/529 - (41%)	Gaps:	87/529 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LVQLPQGKLRG----RDNGSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACL-- 87
            :|..|.|.:||    .|.....::..:|||:||.|..||:..|.. .:||...:|......|.
Worm    40 VVHTPLGTIRGVGQTFDGAKVSAFLGVPYAKPPIGSRRFKMAEMI-DRWSGELEARTLAKTCYLT 103

  Fly    88 ---QWDQFTPGANKL----VGEEDCLTVSVYKPKNSKRNSFPVVAHIHGGAFMFGAAWQNGHENV 145
               .:.|| |||...    ...||||.::::.|::   :...|:..|:||.|..|....:.:...
Worm   104 IDSAFPQF-PGAEMWNPPGAISEDCLNMNIWVPED---HDGSVMVWIYGGGFFSGTPSLDLYSGS 164

  Fly   146 MREGK--FILVKISYRLGPLGFVSTGDRDLP--GNYGLKDQRLALKWIKQNIASFGGEPQNVLLV 206
            :...|  .|:|.::|||||.||:..|| |.|  ||.||.||:|||:|:.:||.:|||:...|.|.
Worm   165 VFAAKEHTIVVNVNYRLGPFGFLYFGD-DSPIQGNMGLMDQQLALRWVHENIGAFGGDRSRVTLF 228

  Fly   207 GHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPW--VIQKGARGRAFELGRNVGCESAEDSTS 269
            |.|||.||....:...:..:..|...:.||:.::.|  .........:|.|.:.|.| |:.|..:
Worm   229 GESAGSASTTAHLFAPNSHKYFRNIIAKSGSIINSWASATPPTMLDLSFRLAKKVNC-SSPDMNA 292

  Fly   270 LKKCLKSKPASELVTA--------VRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGK 326
            :.|||:|.|| .||.|        :...:.|:|||.:..:...:..........|..:||  :..
Worm   293 IVKCLRSVPA-HLVQAEADNISGDIGPPMTFAYVPVSSDANFFQGDVFQKLANKQFKKDV--NII 354

  Fly   327 FGQVP-----WAVSY-------------VTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLL 373
            ||.|.     |...|             ::.:..:|.||:.:        |...|......||
Worm   355 FGSVKDEGTYWLPYYMSLPKYGFAFNHTISAEDPHNRALITR--------DHYEESMRAFMPY-- 409

  Fly   374 FYRDTKTKKD--MDDYSRKIKQEYIGNQRFDIESYSE-LQRLFTDILFKNSTQESLDL--HRKYG 433
             :..:|...:  |:.|      |::.......|.|.: :.|...|:.|..|..:..||  ...:|
Worm   410 -FAGSKLVLNAFMNSY------EHVSTSNVPEERYRDGVARFLGDLFFTCSLIDFADLISDNIFG 467

  Fly   434 KSPAYAYVY---DNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFENFVRDVEMRPDEQIISRNFI 495
            ....|.:.|   .||..|.:..:.....:|.||..:       :...:.|.....||:.:|...:
Worm   468 NVYMYYFTYRSSANPWPKWMGVMHGYEIEYAFGQPY-------WRPHLYDQTHLEDEKRLSSIIM 525

  Fly   496 NMLADFASS 504
            .:.|:||::
Worm   526 QIWANFANT 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	138/529 (26%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	48/138 (35%)
ace-2	NP_491141.1	COesterase	33..546	CDD:278561	138/529 (26%)
ace-2	NP_491141.1	Aes	<135..>233	CDD:223730	40/101 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910