DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Nlgn3

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_599163.2	Gene:	Nlgn3 / 171297	RGDID:	621119	Length:	848	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	150/549 - (27%)
Similarity:	219/549 - (39%)	Gaps:	113/549 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRG-------RDNGSYYSYESIPYAEPPTGDL 61
            ||..|.::|..|.|...||.......|....|||||       ...|....|..:|||.||.|:.
  Rat    18 VGRSLCLILWFLSLVLRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEK 82

  Fly    62 RFEAPEPYKQKWSDIFDATKTPVACLQ-------------WDQFTPGANKLV-----GEEDCLTV 108
            ||..||| ...||.|.:||..|..|.|             |  ||...:.:.     ..||||.:
  Rat    83 RFLPPEP-PPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVW--FTANLDIVATYIQEPNEDCLYL 144

  Fly   109 SVYKP-------------KNSKR------------------------------NSFPVVAHIHGG 130
            :||.|             |.:|:                              .:.||:.:||||
  Rat   145 NVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGG 209

  Fly   131 AFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIAS 195
            ::|.|.........:...|..|::.::||:|.|||:||||:...|||||.||..||:|:.:|||.
  Rat   210 SYMEGTGNMIDGSVLASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAF 274

  Fly   196 FGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNVG 260
            |||:|:.:.:.|...|.:.|.|..|......|.:.|...||:||..|.:..........|...||
  Rat   275 FGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVG 339

  Fly   261 CESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVP---FAPFSPVLEPSDAPDAIITQDPRDVI 322
            | :..|:..:..||:.|.|.|||..       ...|   ...|.||::....||     ||..::
  Rat   340 C-NVLDTVDMVDCLRQKSAKELVEQ-------DIQPARYHVAFGPVIDGDVIPD-----DPEILM 391

  Fly   323 KSGKFGQVPWAVSY-----VTEDGGYNAALLLKERKSGIVIDDLNERWLELAPYLLFYRDTKTKK 382
            :.|:|      ::|     |.:..|......:.:.:.|:...|.:.........|..|.:.|
  Rat   392 EQGEF------LNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGK--- 447

  Fly   383 DMDDYSRKIKQEYIG-NQRFDIESYSE-LQRLFTDILFKNSTQESLDLHRKYGKSPAYAYVYDNP 445
              |.....||..|.. ..|.:.|:..: |..||||..:...:..:.|||.:|| ||.|.|.:.:.
  Rat   448 --DTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYG-SPTYFYAFYHH 509

  Fly   446 AEKGIAQVLANRTDYDFGTVHGDDYFLIF 474
            .:..:....::       ..|||:...:|
  Rat   510 CQSLMKPAWSD-------AAHGDEVPYVF 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	142/524 (27%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	53/175 (30%)
Nlgn3	NP_599163.2	COesterase	40..624	CDD:395084	142/527 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..195		0/25 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..691
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336081
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740