DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Ces2c

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_598270.2	Gene:	Ces2c / 171118	RGDID:	621510	Length:	561	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	153/533 - (28%)
Similarity:	249/533 - (46%)	Gaps:	68/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNYVGLGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRG-----RD-NGSYYSYESIPYAEPPTG 59
            :|.|..||:::|..:| |.::.::..  :.....|::||     || ....:::..||:|:.|.|
  Rat    10 LNAVLFGLLLILIHVW-GQDSPESSS--IRTTHTGQVRGKLDHVRDTKAGVHTFLGIPFAKAPVG 71

  Fly    60 DLRF---EAPEPYKQKWSDIFDATKTPVACLQ----WDQFTPGANKLV-----GEEDCLTVSVYK 112
            .|||   |.|||    ||.:.|.|..|..|||    .|:......|::     ..||||.:::|.
  Rat    72 PLRFAPPEDPEP----WSGVRDGTSHPAMCLQNIDMLDEVGLTDMKMILSSIPMSEDCLYLNIYT 132

  Fly   113 PKNSKRNS-FPVVAHIHGGAFMFG-AAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPG 175
            |.::...| .||:..|||||.:.| |:..:|....:.| ..::|.|.||||.|||.||||....|
  Rat   133 PAHAHEGSNLPVMVCIHGGALVIGMASMCDGSLLAVNE-DLVVVAIQYRLGVLGFFSTGDEHARG 196

  Fly   176 NYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALD 240
            |:|..||..||:|::||||.|||.|..|.:.|.||||.||...::......|...|...||.||.
  Rat   197 NWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGVSAGGTSVSSHVISPMSQGLFHGAIMESGVALL 261

  Fly   241 PWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLE 305
            |.:|.:.:...:..:.:..||| |.||.:|.:||::|..:|::...:.|.:...|....|.|
  Rat   262 PDLISETSETVSTTVAKLSGCE-ATDSETLVRCLRAKSGAEILVINKVFKMIPAVVDGEFLP--- 322

  Fly   306 PSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDDLNERWLELAP 370
                      :.|::::.|..|..||..:...|::......:::...:   :|.:|:...|:..
  Rat   323 ----------RHPKELLASEDFHPVPSIIGVNTDEYCCTIPMVMGTAQ---IIKELSRENLQAV- 373

  Fly   371 YLLFYRDTKTKKDM-DDYSRKIKQEYIGN----QRFDIESYSELQRLFTDILFKNSTQESLDLHR 430
                .:||..:..: .:....:.:||:||    |...|: |:|   :..|.||.....:.....|
  Rat   374 ----LKDTAAQMMLPPECGDLLMEEYMGNTDDPQTLQIQ-YAE---MMGDFLFVIPALQVAHFQR 430

  Fly   431 KYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFENFV--RDVEMRPDEQIISRN 493
            .:  :|.|.|.:.: |......|.......|    |.|:...:|.:|.  ..|:...:|:::||.
  Rat   431 SH--APVYFYEFQH-APSYFKNVRPPHVKAD----HADEVPFVFGSFFWGIKVDFTEEEKLLSRR 488

  Fly   494 FINMLADFASSDN 506
            .:...|:||...|
  Rat   489 MMKYWANFARHGN 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	146/505 (29%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	58/134 (43%)
Ces2c	NP_598270.2	COesterase	32..540	CDD:395084	146/510 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910