DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Ces3b

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_653094.2	Gene:	Ces3b / 13909	MGIID:	3644960	Length:	571	Species:	Mus musculus

Alignment Length:	548	Identity:	147/548 - (26%)
Similarity:	227/548 - (41%)	Gaps:	96/548 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GLGLIIVLSCLWLGSNASDTDDPLL---VQLPQGKLRGRDNG------SYYSYESIPYAEPPTGD 60
            |..:::.::||.|....:.|...::   |..|.|::|||..|      ....:..||:|:.|.|.
Mouse    11 GSSVLVWVTCLLLAFVTTVTGPKVIQPEVDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPVGP 75

  Fly    61 LRFEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVG--------------EEDCLTVSVY 111
            |||.||.| .|.|..:.||:..|..|||      ...|::.              .|||||:::|
Mouse    76 LRFSAPLP-PQPWEGVRDASINPPMCLQ------DVEKMINSRFGLNEKIKIFPISEDCLTLNIY 133

  Fly   112 KP----KNSKRNSFPVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRD 172
            .|    ...||   ||:..||||:.:.|::.......:...|..::|.:.||||..||:||||:.
Mouse   134 SPTEITAGDKR---PVMVWIHGGSLLVGSSTSQDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKH 195

  Fly   173 LPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSG- 236
            :|||.|..|...||:|::.|||.|||:|..|.:.|:||||..|....|......|...|.|.||
Mouse   196 MPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGI 260

  Fly   237 ------NALDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYV 295
                  ..:.||       ..|.....:|.|.||..: .|.:||..|...:|:.  :|.:..||:
Mouse   261 VTTIMMEDMKPW-------PEAQNFANSVACGSASPA-ELVQCLLQKEGKDLIK--QKNVNISYI 315

  Fly   296 PFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVIDD 360
                         ..|:...|.|..::...:|..||:.:.....:.|:   ||||...   ::|.
Mouse   316 -------------VNDSFFPQRPEKLLADQQFPTVPYLLGVTNHEFGW---LLLKSLN---ILDK 361

  Fly   361 L----NERWLELA-PYLLFYRDTKTKKDMD---DYSRKIKQEYIGNQRFDIESYSELQRLFTDIL 417
            |    .|..||:: |:|..         |:   :....:..||:.|......:....|.|..||.
Mouse   362 LEHLSREDLLEISRPFLAI---------MEVPPEIMPTVIDEYLDNGSDQSATRYAFQELLGDIS 417

  Fly   418 FKNSTQESLDLHRKYGKSPAYAYVYDNP----AEKGIAQVLANRTDYDFGTVHGDDYFLIFENFV 478
            |...|.......|..| .|.:.|.:.:.    |:...|.|.|:... :...|.|..:.....:.:
Mouse   418 FIIPTLNFSKYLRDAG-CPVFLYEFQHTPSSFAKFKPAWVKADHAS-ENSFVFGGPFLTDESSLL 480

  Fly   479 RDVEMRPDEQIISRNFINMLADFASSDN 506
            ...|...:|:.:|...:...:.||.:.|
Mouse   481 AFPEATEEEKQLSLTMMAQWSQFARTGN 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	142/524 (27%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	52/143 (36%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	142/523 (27%)
		Aes	75..>245	CDD:223730	66/179 (37%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832473
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840