DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Ces1e

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_598421.1	Gene:	Ces1e / 13897	MGIID:	95432	Length:	562	Species:	Mus musculus

Alignment Length:	559	Identity:	155/559 - (27%)
Similarity:	251/559 - (44%)	Gaps:	84/559 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LGLIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGRDNGSYYSYE----------SIPYAEPPTGD 60
            |..:|::|.....:.|.....|.:|...|||:.|:    |.|.|          .:|:|:||.|.
Mouse     3 LSALILVSLAAFTAGAGHPSSPPMVDTVQGKVLGK----YISLEGFTQPVAVFLGVPFAKPPLGS 63

  Fly    61 LRFEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVGE--------------EDCLTVSVY 111
            |||..|:| .:.||.:.:||..|..|.|    .|...::|.:              ||||.:::|
Mouse    64 LRFAPPQP-AEPWSSVKNATSYPPMCFQ----DPVTGQIVNDLLTNRKEKIPLQFSEDCLYLNIY 123

  Fly   112 KPKN-SKRNSFPVVAHIHGGAFMF-GAAWQNG-----HENVMREGKFILVKISYRLGPLGFVSTG 169
            .|.: :|.:..||:..||||..:. ||:..:|     ||||      ::|.|.||||..||.|||
Mouse   124 TPADLTKSDRLPVMVWIHGGGLVLGGASTYDGLVLSTHENV------VVVVIQYRLGIWGFFSTG 182

  Fly   170 DRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSF 234
            |....||:|..||..||.|::.|||.|||:|.:|.:.|.||||.||.:.:|......|.:.|.|.
Mouse   183 DEHSRGNWGHLDQVAALHWVQDNIAKFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFQRAISE 247

  Fly   235 SGNALDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSY----- 294
            ||.||...:::|..|..|.::....||::. .|.::..||:.|...||:....|..:|..
Mouse   248 SGVALTAGLVKKNTRPLAEKIAVISGCKNT-TSAAMVHCLRQKTEEELLGTTLKLNLFKLDLHGD 311

  Fly   295 ----VPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSG 355
                .||.|  .||:     ..::.:.|.:::....|..||:.|....::.|:....::....|.
Mouse   312 SRQSHPFVP--TVLD-----GVLLPKMPEEILAEKNFNTVPYIVGINKQEFGWILPTMMNYPPSD 369

  Fly   356 IVIDDLNE-RWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFK 419
            :.:|.:.. ..|:.:.:||...:......::.|.|  .::|.|..:      .:|..|..|::|.
Mouse   370 VKLDQMTAMSLLKKSSFLLNLPEDAIAVAIEKYLR--DKDYTGRNK------DQLLELIGDVVFG 426

  Fly   420 NSTQESLDLHRKYGKSPAYAYVYD-NPAEKGIAQVLANRTDYDFGTVHGDDYFLIFENFVRDVEM 483
            ..:......||..| :|.|.|.:. :|:...     ..:.|...|. |||:.:.:|...:.....
Mouse   427 VPSVIVSRGHRDAG-APTYMYEFQYSPSFSS-----EMKPDTVVGD-HGDEIYSVFGAPILRGGT 484

  Fly   484 RPDEQIISRNFINMLADFASSDN----GSLKYGECDFKD 518
            ..:|..:|:..:...|:||.:.|    |...:.|.|.|:
Mouse   485 SEEEINLSKMMMKFWANFARNGNPNGQGLPHWPEYDQKE 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	150/536 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	59/139 (42%)
Ces1e	NP_598421.1	COesterase	25..546	CDD:278561	150/537 (28%)
		Aes	44..>242	CDD:223730	76/208 (37%)
		Prevents secretion from ER. /evidence=ECO:0000255	559..562
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832792
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840