DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Est-6 and Ces1c

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_031980.2	Gene:	Ces1c / 13884	MGIID:	95420	Length:	554	Species:	Mus musculus

Alignment Length:	543	Identity:	150/543 - (27%)
Similarity:	228/543 - (41%)	Gaps:	133/543 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PLLVQLPQGKLRGRDNGSYYSYE----------SIPYAEPPTGDLRFEAPEPYKQKWSDIFDATK 81
            |.:|...|||:.|:    |.|.|          .:|:|:||.|.|||..|:| .:.||.:.:||.
Mouse    23 PPVVDTTQGKVLGK----YISLEGFEQPVAVFLGVPFAKPPLGSLRFAPPQP-AEPWSFVKNATS 82

  Fly    82 TPVACLQ---W-----DQFTPGAN--KLVGEEDCLTVSVYKPKN-SKRNSFPVVAHIHGGAFMF- 134
            .|..|.|   |     |.|:....  .|...||||.:::|.|.: :|.:..||:..||||..:.
Mouse    83 YPPMCSQDAGWAKILSDMFSTEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGLVIG 147

  Fly   135 GAAWQNG-----HENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIA 194
            ||:..||     ||||      ::|.|.||||..|..||||...|||:...||..||:|::.|||
Mouse   148 GASPYNGLALSAHENV------VVVTIQYRLGIWGLFSTGDEHSPGNWAHLDQLAALRWVQDNIA 206

  Fly   195 SFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNV 259
            :|||.|.:|.:.|.|:||.||.:.:|......|...|.|.||..::..|.:|..:.....:....
Mouse   207 NFGGNPDSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVINTNVGKKNIQAVNEIIATLS 271

  Fly   260 GCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPDAIITQDPRDVIKS 324
            .|... .|.::.:||:.|..|||:....|.:.::    ...|.:::     ..::.:.|.:::..
Mouse   272 QCNDT-SSAAMVQCLRQKTESELLEISGKLVQYN----ISLSTMID-----GVVLPKAPEEILAE 326

  Fly   325 GKFGQVPWAVSYVTEDGGYNAAL----LLKERKSGIVIDDLNERWLELAPYLL--FYRDTKTKKD 383
            ..|..||:.|.:..::.|:...:    ||.|.|       :||   |.|..||  |:.:....:.
Mouse   327 KSFNTVPYIVGFNKQEFGWIIPMMLQNLLPEGK-------MNE---ETASLLLRRFHSELNISES 381

  Fly   384 M-----DDYSRKIKQEYIGNQRFDIESYSEL-QRLFTDILFKNSTQESLDLHRKYGKSPAYAYVY 442
            |     :.|.|.:.         |....||| ..:|.||.|
Mouse   382 MIPAVIEQYLRGVD---------DPAKKSELILDMFGDIFF------------------------ 413

  Fly   443 DNPAEKGIAQVLANRTDYDFG---------------------TV---HGDDYFLIFENFVRDVEM 483
                  ||..||.:|:..|.|                     ||   |||:.|.:|...:.....
Mouse   414 ------GIPAVLLSRSLRDAGVSTYMYEFRYRPSFVSDKRPQTVEGDHGDEIFFVFGAPLLKEGA 472

  Fly   484 RPDEQIISRNFINMLADFASSDN 506
            ..:|..:|:..:...|:||.:.|
Mouse   473 SEEETNLSKMVMKFWANFARNGN 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	149/541 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	56/139 (40%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	149/541 (28%)
		Aes	<121..>234	CDD:223730	51/118 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832536
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840