DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Cel

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_034015.1	Gene:	Cel / 12613	MGIID:	88374	Length:	599	Species:	Mus musculus

Alignment Length:	500	Identity:	152/500 - (30%)
Similarity:	235/500 - (47%)	Gaps:	89/500 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 YESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQWDQFTPGANKLVGEEDCLTVSVYK 112
            ::.||:|...|    .|.|:.: ..|.....||.....||   |.|...:...|:||||.::::.
Mouse    51 FKGIPFATAKT----LENPQRH-PGWQGTLKATNFKKRCL---QATITQDNTYGQEDCLYLNIWV 107

  Fly   113 PKNSKR--NSFPVVAHIHGGAFMFGAAWQNGH---------ENVMREGKFILVKISYRLGPLGFV 166
            |:..|:  ::.||:..|:||||:.|:. |..:         |.:...|..|:|..:||:|||||:
Mouse   108 PQGRKQVSHNLPVMVWIYGGAFLMGSG-QGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFL 171

  Fly   167 STGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAA 231
            ||||.:||||:||:||.:|:.|:|:|||:|||:|.|:.:.|.|||.|||.||.|......|.|.|
Mouse   172 STGDANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRA 236

  Fly   232 FSFSGNALDPWVIQKGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVR---KFLIFS 293
            .|.||.||.||.|||.....|..:.:.|||.: ||:..:..|||......|..|.:   |...:.
Mouse   237 ISQSGMALSPWAIQKNPLFWAKTIAKKVGCPT-EDTGKMAACLKITDPRALTLAYKLPVKKQEYP 300

  Fly   294 YVPFAPFSPVLEPSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLKERKSGIVI 358
            .|.:..|.||::....||     ||.::..:             |.|..|.|.:...:......|
Mouse   301 VVHYLAFIPVIDGDFIPD-----DPINLYNN-------------TADIDYIAGINNMDGHLFATI 347

  Fly   359 DDLNERWLELAPYLLFYRDTKTKKDM--DDYSRKIKQEYI-----GNQ-RFDI--ESYSE----- 408
            |         .|.:     .|||:.:  :|:.|.:....:     |.| .|||  ||:::
Mouse   348 D---------VPAV-----DKTKQTVTEEDFYRLVSGHTVAKGLKGAQATFDIYTESWAQDPSQE 398

  Fly   409 -----LQRLFTDILFKNSTQESLDLHRKYGKS-PAYAYVYDNPAEKGIAQVLANRTDYD--FGTV 465
                 :....||:||...|:.:|..|:.:.|| ..|:|::.:|:...|         |.  .|..
Mouse   399 NMKKTVVAFETDVLFLIPTEIALAQHKAHAKSAKTYSYLFSHPSRMPI---------YPKWMGAD 454

  Fly   466 HGDDYFLIF-ENFVRDVEMRPDEQIISRNFINMLADFASSDNGSL 509
            |.||...:| :.|...:..||.::.:|:..|....:||.|.:.::
Mouse   455 HADDLQYVFGKPFATPLGYRPQDRAVSKAMIAYWTNFARSGDPNM 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	152/499 (30%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	64/143 (45%)
Cel	NP_034015.1	COesterase	26..542	CDD:278561	152/499 (30%)
		Aes	<117..>247	CDD:223730	61/130 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..599
		4 X 11 AA tandem repeats, O-glycosylated region	559..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832778
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740