DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and Bche

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	XP_011238302.1	Gene:	Bche / 12038	MGIID:	894278	Length:	615	Species:	Mus musculus

Alignment Length:	557	Identity:	159/557 - (28%)
Similarity:	255/557 - (45%)	Gaps:	116/557 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LIIVLSCLWLGSNASDTDDPLLVQLPQGKLRGRD----NGSYYSYESIPYAEPPTGDLRFEAPEP 68
            |.|:|.|:..|.  |.|::..::....|::||..    .|:..::..||||:||.|.|||:.|:|
Mouse    27 LWILLLCMPFGK--SHTEEDFIITTKTGRVRGLSMPVLGGTVTAFLGIPYAQPPLGSLRFKKPQP 89

  Fly    69 YKQKWSDIFDATKTPVACLQ-WDQFTPG--ANKLVG-----EEDCLTVSVY----KPKNSKRNSF 121
            . .||.||.:||:...:|.| .||..||  .:::..     .||||.::|:    ||||:
Mouse    90 L-NKWPDIHNATQYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWIPVPKPKNA----- 148

  Fly   122 PVVAHIHGGAFMFGAAWQNGHENV-MREGKF-------ILVKISYRLGPLGFVS-TGDRDLPGNY 177
            .|:..|:||.|      |.|..:: :.:|||       |:|.::||:|.|||:: .|:.|.|||.
Mouse   149 TVMVWIYGGGF------QTGTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLAFPGNPDAPGNM 207

  Fly   178 GLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPW 242
            ||.||:|||:|:::|||:|||.|:::.:.|.|||.|||.|.:|......|...|...||::..||
Mouse   208 GLFDQQLALQWVQRNIAAFGGNPKSITIFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPW 272

  Fly   243 VIQ--KGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLE 305
            .::  :.||.|...|.:..|| |.|:...:.|||:||...|::...|..|....:....|.|.::
Mouse   273 AVKHPEEARNRTLTLAKFTGC-SKENEMEMIKCLRSKDPQEILRNERFVLPSDSILSINFGPTVD 336

  Fly   306 PSDAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGG-----YNAALLLKERKSGIVIDDLNERW 365
            ..     .:|..|..:::.||..:....|. |.:|.|     |.|....|:..|.|...:..|..
Mouse   337 GD-----FLTDMPHTLLQLGKVKKAQILVG-VNKDEGTAFLVYGAPGFSKDNDSLITRKEFQEGL 395

  Fly   366 LELAP---------YLLFYRDTKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNS 421
            ....|         .|.:|.|...::..:.| |....:.||:.                    |.
Mouse   396 NMYFPGVSRLGKEAVLFYYVDWLGEQSPEVY-RDALDDVIGDY--------------------NI 439

  Fly   422 TQESLDLHRKYG--KSPAYAYVYDNPAEKGIAQVLANRTDYD--FGTVHGDDYFLIF-------E 475
            ...:|:..:|:.  ::.|:.|.:::.:.|         ..:.  .|.:||.:...:|       .
Mouse   440 ICPALEFTKKFAELENNAFFYFFEHRSSK---------LPWPEWMGVMHGYEIEFVFGLPLGRRV 495

  Fly   476 NFVRDVEMRPDEQIISRNFINMLADFASSDNGSLKYG 512
            |:.|      .|:|.||:.:...|:||       |||
Mouse   496 NYTR------AEEIFSRSIMKTWANFA-------KYG 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	152/536 (28%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	57/145 (39%)
Bche	XP_011238302.1	COesterase	46..563	CDD:365897	152/536 (28%)
Bche	XP_011238302.1	AChE_tetra	578..612	CDD:370053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910