DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and clt

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	174/536 - (32%)
Similarity:	255/536 - (47%)	Gaps:	51/536 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VQLPQGKLRGRD----NG-SYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVACLQW 89
            |.:.||.|.||.    || .|.|:..:||||||.|:|||.:|.|.::......|.:|......|.
  Fly    22 VPVKQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSYQR 86

  Fly    90 DQFTPGANKLVGEEDCLTVSVYKPK-NSKRNSFPVVAHIHGGAFMFGAAWQNGHENV-----MRE 148
            |.||   .::.|.||||.::||.|| .|.|...||:..||||.|.||    ||:.:.     :.|
  Fly    87 DPFT---LEVAGSEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFG----NGNSDFHFPAKLME 144

  Fly   149 GKFILVKISYRLGPLGFVSTGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAGGA 213
            .:.|:|.::||||.|||:|..:..:.||.|||||||||:|:::|||||.|:|.||.|.|.||||:
  Fly   145 QEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGS 209

  Fly   214 SVHLQMLREDFGQLARAAFSFSGNALDPWVIQKGARGRAFELGRNV-GCESAEDSTSLKKCLKSK 277
            ||||........:|...|...||.|...||.|..|..:...|...: |.:...||.:|...|:|:
  Fly   210 SVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAKTRRLAELLGGGDFGGDSKALLTFLQSE 274

  Fly   278 PASELVTAVRKFLIFS------YVPFAPFSPVLEPSDAPDAIITQDPRDVI-KSGKFGQVPWAVS 335
            .|:..........:.|      ::||| |.||:|.|.:||..:.||..::: |....|.:|..:.
  Fly   275 KATPTAILANTLKVLSPDERRRHLPFA-FKPVVEDSSSPDRFLEQDIMELMHKKDCLGSMPVIMG 338

  Fly   336 YVTEDGGYNAALLLK-ERKSGIVIDDLNE---RWLELAPYLLFYRDTKTKKDMDDYSRKIKQEYI 396
            |.:.:|   .|:::| ::|.....|||..   |.|.|.|         ...:..:.:..|:..:.
  Fly   339 YNSAEG---LAIVVKAKQKLEAYEDDLARLVPRNLVLDP---------QAPEAQEAASDIRAFFF 391

  Fly   397 GNQRFDIESYSELQRLFTDILFKNSTQESLDLHRK-YGKSPAYAYVYDNPAEKGIAQVLANRTDY 460
            ..|....|:...|..||:|..|....|.::::|.. ..:||.|.|..|....:.:.:.:....|.
  Fly   392 NGQALSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNLYKKIFQNEDL 456

  Fly   461 DFGTVHGDDYFLIFENFVRDVEMRPDEQIISRNFINMLADFASSDNGSLKYGECDFKDNVGSEKF 525
            . |..|.||...:|:....:.||..|:.:::.....|.|:||.....|..:.......|  .|..
  Fly   457 R-GVAHADDICYLFQMAGDETEMNRDDLMVTERLCEMWANFARDGKPSPIWKPVKKPHN--GEPI 518

  Fly   526 QLLAIYIDG----CQN 537
            ||..:.||.    |.|
  Fly   519 QLDCLLIDRELKMCSN 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	173/534 (32%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	64/138 (46%)
clt	NP_536784.1	COesterase	22..543	CDD:278561	174/536 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.960