Protein Alignment Est-6 and Nlgn2

DIOPT Version :10

• Sequence 1: NP_788500.1
• Gene: Est-6 / 39392
• FlyBaseID: FBgn0000592
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_446444.1
• Gene: Nlgn2 / 117096
• RGDID: 621118
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 139/505 - (27%)
• Similarity: 205/505 - (40%)
• Gaps: 98/505 - (19%)

  Fly    29 LVQLPQGKLRG----RDN---GSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATKTPVAC 86
            :|....|::||    .:|   |....:..:|||.||.|..||:.||. ...|..:.:||..|.||
  Rat    43 VVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEA-PASWPGVRNATTLPPAC 106

  Fly    87 LQ-------------W--DQFTPGANKLVGE-EDCLTVSVYKPK-----NSKRNSF--------- 121
            .|             |  |.....|..:..: ||||.:::|.|.     ..||:..
  Rat   107 PQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDI 171

  Fly   122 ------PVVAHIHGGAFMFGAAWQNGHENVMREGKFILVKISYRLGPLGFVSTGDRDLPGNYGLK 180
                  ||:..:|||::|.|.........:...|..|:..::||||.|||:||||:...|||||.
  Rat   172 RDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLL 236

  Fly   181 DQRLALKWIKQNIASFGGEPQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPWVIQ 245
            ||..||:|:.:|||.|||:|:.:.:.|..||.:.|:|.:|......|.:.|.:.||.|:..|.:.
  Rat   237 DQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVN 301

  Fly   246 KGARGRAFELGRNVGCESAEDSTSLKKCLKSKPASELV---TAVRKFLIFSYVPFAPFSPVLEPS 307
            .........|...|||: .||||...:||:.|.:.|||   ....::.|       .|.||::..
  Rat   302 YQPLKYTRLLAAKVGCD-REDSTEAVECLRRKSSRELVDQDVQPARYHI-------AFGPVVDGD 358

  Fly   308 DAPDAIITQDPRDVIKSGKFGQVPWAVSYVTEDGGYNAALLLK------ERKSGIVIDDLNERWL 366
            ..||     ||..:::.|:|......:       |.|....||      |.:.|:.....:....
  Rat   359 VVPD-----DPEILMQQGEFLNYDMLI-------GVNQGEGLKFVEDSAESEDGVSASAFDFTVS 411

  Fly   367 ELAPYLLFYRDTKTKKDMDDYSRKIKQEYI-------GNQRFDIESYSELQRLFTDILFKNSTQE 424
            .....|..|.:.|     |.....||..|.       |..|     ...|..||||..:......
  Rat   412 NFVDNLYGYPEGK-----DVLRETIKFMYTDWADRDNGEMR-----RKTLLALFTDHQWVAPAVA 466

  Fly   425 SLDLHRKYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIF 474
            :..||..| :||.|.|.:.:..:      ...|.:: ....|||:...:|
  Rat   467 TAKLHADY-QSPVYFYTFYHHCQ------AEGRPEW-ADAAHGDELPYVF 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_788500.1	Esterase_lipase	29..537	CDD:238191	139/505 (28%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	139/505 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836