DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-6 and ache

DIOPT Version :9

Sequence 1:	NP_001261749.1	Gene:	Est-6 / 39392	FlyBaseID:	FBgn0000592	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_571921.1	Gene:	ache / 114549	ZFINID:	ZDB-GENE-010906-1	Length:	634	Species:	Danio rerio

Alignment Length:	557	Identity:	160/557 - (28%)
Similarity:	245/557 - (43%)	Gaps:	115/557 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SDTDDPLLVQLPQGKLRGR-----DNGSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATK 81
            :..:..|:|....|:::|.     |.....::..|||||||.|..||:..|| |:.|:::|:|.:
Zfish    23 AQAEPDLVVATRLGRVQGTRLPVPDRSHVIAFLGIPYAEPPIGKRRFKRAEP-KKPWNNVFEAKE 86

  Fly    82 TPVACLQW-DQFTPG--------ANKLVGEEDCLTVSVYKPKNSKRNSFPVVAHIHGGAFMFGAA 137
            ...||.|: |...||        .|::: .||||.::|:.|...:..:..|:..|:||.|..|::
Zfish    87 FSNACYQFVDTSYPGFPGIEMWNPNRVM-SEDCLYLNVWVPPTPRPQNLTVMVWIYGGGFYSGSS 150

  Fly   138 WQNGHEN--VMREGKFILVKISYRLGPLGFVS-TGDRDLPGNYGLKDQRLALKWIKQNIASFGGE 199
            ..:.::.  :....|.::|.::||:|..||:: .|..|.|||.||.||||||:|:::||..|||.
Zfish   151 SLDVYDGRYLAYTEKVVVVSMNYRVGAFGFLALNGSSDAPGNVGLYDQRLALQWVQENIHFFGGN 215

  Fly   200 PQNVLLVGHSAGGASVHLQMLREDFGQLARAAFSFSGNALDPW--VIQKGARGRAFELGRNVGCE 262
            |:.|.:.|.|||.|||.:.:|..|...|...|...||....||  |....||.|..:||:.|||.
Zfish   216 PKQVTIFGESAGAASVGMHVLSPDSRPLFTRAILQSGVPNTPWATVTFDEARRRTTKLGKLVGCT 280

  Fly   263 SAEDSTSLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEP---SDAPDAIITQDPRDVIKS 324
            ...| |.|..||::|...||:....:.|.:|.:....|.||::.   .|.|||:|:        |
Zfish   281 WGND-TELIDCLRNKHPQELIDQEWQVLPWSSLFRFSFVPVVDGVFFPDTPDAMIS--------S 336

  Fly   325 GKFGQVPWAVSYVTEDGGY------------NAALLLKER-----KSGIVIDDLNERWLELAPYL 372
            |.|......:....::|.|            |.:|:.:|.     |.|  :...|:..||..  :
Zfish   337 GNFKYTQILLGVNQDEGSYFLLYGAPGFSKDNESLISREDFLESVKMG--VPHANDIGLEAV--I 397

  Fly   373 LFYRD-------TKTKKDMDDYSRKIKQEYIGNQRFDIESYSELQRLFTDILFKNSTQESLDLHR 430
            |.|.|       .|.:..|||        .:|:|..    ...||.      |..|..:...||
Zfish   398 LQYTDWMDENNGQKNRDAMDD--------IVGDQNV----ICPLQH------FAKSYAQYAALH- 443

  Fly   431 KYGKSPAYAYVYDNPAEKGIAQVLANRTDYDFGTVHGDDYFLIFEN------------------- 476
              .:|.|.|     |...|...  :..|.|:.|..||..|..:|::
Zfish   444 --AQSSAAA-----PGTLGWGN--SGPTGYNSGNSHGAVYLYLFDHRASNLAWPEWMGVIHGYEI 499

  Fly   477 ---FVRDVEMR----PDEQIISRNFINMLADFASSDN 506
               |...:|.|    .:|:.:||..:...|:||.:.|
Zfish   500 EFVFGLPLEKRLNYTAEEEKLSRRIMRYWANFARTGN 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-6	NP_001261749.1	Esterase_lipase	29..537	CDD:238191	159/550 (29%)
Est-6	NP_001261749.1	Aes	<110..>243	CDD:223730	51/137 (37%)
ache	NP_571921.1	COesterase	23..583	CDD:278561	160/557 (29%)
ache	NP_571921.1	AChE_tetra	598..631	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575538
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840